产品类型:病理抗体

英文名称:Ki-67 Mouse mAb

中文名称:Ki67蛋白单克隆抗体

产品应用:IHC-P, IHC-F, Flow-Cyt

交叉反应:Human, Rat (predicted: Mouse)

抗体来源:Mouse

免疫原:KLH conjugated synthetic peptide derived from human Ki-67:

亚型:IgG

性状:Liquid

纯化方法:affinity purified by Protein G

克隆类型:Monoclonal

克隆号:6B9

理论分子量:358 kDa

检测分子量:18 kDa kDa

浓度:1mg/ml

储存液:0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

功能:Thought to be required for maintaining cell proliferation.

亚细胞定位:

Nucleus. Chromosome. Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes.

相似性:Contains 1 FHA domain.

SWISS:P46013

Gene ID:4288

保存条件:Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

注意事项:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

背景资料

Ki67 antigen is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 antibodies are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki67 positive cells among the total number of resting cells = Ki67 index). In neoplastic tissues the prognostic value is comparable to the tritiated thymidine labelling index. The correlation between low Ki67 index and histologically low grade tumours is strong. Ki67 is routinely used as a neuronal marker of cell cycling and proliferation

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