产品应用:IHC-P, IHC-F, IF, ELISA

交叉反应:Human (predicted: 8-OHdG)

抗体来源:Rabbit

免疫原:KLH conjugated 8-OHdG:

亚型:IgG

性状:Liquid

纯化方法:affinity purified by Protein A

克隆类型:Polyclonal

理论分子量:0.283 kDa

浓度:1mg/ml

储存液:0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

功能:

Oxoguanine 8 (8-Oxoguanine) is a mutagenic oxidative damage product of guanine. Guanine is the main target for reactive oxygen species in DNA, with 8-oxoguanine being the most frequent base lesion. Thus formation of 8-oxoguanine is an important biomarker of oxidative damage to DNA. It is primarily repaired by the DNA glycosylase OGG1.

保存条件:Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

背景资料

8-Hydroxydeoxyguanosine (8OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer's disease.