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BN42190R-50ul
50ul
¥1338.00
交叉反应（总）:Mouse,Rat,;推荐应用:WB ELISA IHC-P IHC-F IF
BN42190R-100ul
100ul
¥2120.00
交叉反应（总）:Mouse,Rat,;推荐应用:WB ELISA IHC-P IHC-F IF
BN42190R-200ul
200ul
¥3140.00
交叉反应（总）:Mouse,Rat,;推荐应用:WB ELISA IHC-P IHC-F IF
| 英文名称 | IL-17 |
| 中文名称 | 白介素-17抗体 |
| 别 名 | Interleukin-17; CTLA 8; CTLA8; Cytotoxic T lymphocyte associated antigen 8; Cytotoxic T lymphocyte associated protein 8; Cytotoxic T lymphocyte associated serine esterase 8; IL 17A; IL17A; IL-17A; Interleukin 17; Interleukin 17A; Interleukin17; Interleukin17A. |
| 研究领域 | 肿瘤 细胞生物 免疫学 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 15kDa |
| 细胞定位 | 分泌型蛋白 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse IL-17:85-150/150 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | IL17, also known as CTLA8, is a T cell derived hematopoietic cytokine. It was originally cloned from a T cell hybridoma produced by fusion of a mouse cytotoxic T cell clone and a rat T lymphoma. IL17 exhibits multiple biological activities on a variety of cells including: the induction of IL6, IL8 and GCSF production in fibroblasts; the enhancement of surface expression of ICAM 1 in fibroblasts; activation of NF kappaB and costimulation of T cell proliferation. IL17 is an approximately 16 kDa polypeptide of 136 amino acids. The precursor form of IL17 consists of 155 amino acids. To generate the mature IL17 (136 amino acids), the precursor cleaves a 19 amino acid signal peptide. Human IL17 shows approximately 62.5% amino acid homology to mouse IL17 and 58% amino acid homology to rat IL17. Function: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Subunit: Homodimer. Subcellular Location: Secreted. Tissue Specificity: Restricted to a subset of activated T-cells. Post-translational modifications: Found both in glycosylated and nonglycosylated forms. Similarity: Belongs to the IL-17 family. SWISS: Q62386 Gene ID: 16171 Database links: Entrez Gene: 3605 Human Entrez Gene: 16171 Mouse Omim: 603149 Human SwissProt: Q16552 Human SwissProt: Q62386 Mouse Unigene: 41724 Human Unigene: 5419 Mouse Unigene: 218513 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 白细胞介素17（IL-17A）是一种来源于活化T淋巴细胞的细胞因子,具有较广泛的生物学活性,它能够通过诱导基质细胞产生前炎性细胞因子和造血细胞因子参与机体免疫调节及部分炎症反应，因此白细胞介素IL-17A可能是某些疾病发生发展的重要因素之一。Interleukin-17 原称CTLA-8, 是T细胞表达的多肽，参与造血干系统的调节，已经显示IL-17促进纤维母细胞产生IL-6，IL-8和G-CSF。 |
