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成骨相关转录因子抗体
  • 产品货号：
    BN42187R
  • 中文名称：
    成骨相关转录因子抗体
  • 英文名称：
    Rabbit anti-Osterix Polyclonal antibody

  • 货号

    产品规格

    售价

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  • BN42187R-50ul

    50ul

    ¥1486.00

    交叉反应：Human,Mouse(predicted:Rat,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

  • BN42187R-100ul

    100ul

    ¥2360.00

    交叉反应：Human,Mouse(predicted:Rat,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

英文名称Osterix
中文名称成骨相关转录因子抗体
别    名Osterix; MGC126598; Osx; Sp 7; Sp7; Sp7 transcription factor; Transcription factor Sp7; Zinc finger protein osterix; SP7_HUMAN.  


研究领域细胞生物  染色质和核信号  信号转导  干细胞  转录调节因子  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量45kDa
细胞定位细胞核 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Osterix:331-431/431 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.[provided by RefSeq, Jul 2010]

Function:
Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity).

Subunit:
Interacts with NO66; the interaction is direct and inhibits transcription activator activity.

Subcellular Location:
Nucleus.

Tissue Specificity:
Osteoblast/chondrocyte specific.

DISEASE:
Osteogenesis imperfecta 12 (OI12) [MIM:613849]: A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI12 is an autosomal recessive form characterized by recurrent fractures, mild bone deformations, generalized osteoporosis, delayed teeth eruption, no dentinogenesis imperfecta, normal hearing, and white sclerae. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the Sp1 C2H2-type zinc-finger protein family.
Contains 3 C2H2-type zinc fingers.

SWISS:
Q8TDD2

Gene ID:
121340

Database links:

Entrez Gene: 121340 Human

Entrez Gene: 170574 Mouse

Entrez Gene: 300260 Rat

Omim: 606633 Human

SwissProt: Q8TDD2 Human

SwissProt: Q5RM08 Mouse

SwissProt: Q8VI67 Mouse

SwissProt: Q6IMK1 Rat

 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Osterix成骨相关转录因子是一种具有锌指基序结构域的转录因子，在体内的表达对成骨细胞具有特异性。该蛋白只在发育的骨组织中特异性表达，是成骨细胞分化和骨形成过程中所必需的转录因子。骨髓基质干细胞分化为表达典型的成骨性标志基因的成骨细胞需要OSX的调控。

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