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Ⅹ型胶原抗体
  • 产品货号：
    BN42178R
  • 中文名称：
    Ⅹ型胶原抗体
  • 英文名称：
    Rabbit anti-Collagen X Polyclonal antibody

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  • BN42178R-50ul

    50ul

    ¥1338.00

    交叉反应（总）:Human,Mouse,Rat,Chicken,Dog,Cow,Rabbit,;推荐应用:WB ELISA IHC-P IHC-F IF

  • BN42178R-100ul

    100ul

    ¥2120.00

    交叉反应（总）:Human,Mouse,Rat,Chicken,Dog,Cow,Rabbit,;推荐应用:WB ELISA IHC-P IHC-F IF

  • BN42178R-200ul

    200ul

    ¥3140.00

    交叉反应（总）:Human,Mouse,Rat,Chicken,Dog,Cow,Rabbit,;推荐应用:WB ELISA IHC-P IHC-F IF

英文名称Collagen X
中文名称Ⅹ型胶原抗体
别    名Collagen type X; Col10a 1; Collagen alpha 1(X) chain; Collagen type X alpha 1 (Schmid metaphyseal chondrodysplasia); Collagen type X alpha 1; Collagen X alpha 1 polypeptide; CollagenX; fa66d11; fb10c08; OTTHUMP00000040411; Procollagen type X alpha 1; Schmid metaphyseal chondrodysplasia; wu:fa66d11; wu:fb10c08; COAA1_HUMAN; COL10A1; Collagen alpha-1(X) chain; collagen alpha-1(X) chain precursor; Schmid metaphyseal chondrodysplasia; collagen X, alpha-1 polypeptide.  



研究领域细胞生物  免疫学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,  (predicted: Human, Chicken, Dog, Cow, Rabbit, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量73kDa
细胞定位细胞外基质 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Collagen X:601-680/680 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD). [provided by RefSeq, Jul 2008].

Function:
Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage.

Subunit:
Homotrimer.

Subcellular Location:
Secreted, extracellular space, extracellular matrix.

Tissue Specificity:
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

DISEASE:
Schmid type metaphyseal chondrodysplasia (SMCD) [MIM:156500]: Dominantly inherited disorder of the osseous skeleton. The cardinal features of the phenotype are mild short stature, coxa vara and a waddling gait. Radiography usually shows sclerosis of the ribs, flaring of the metaphyses, and a wide irregular growth plate, especially of the knees. A variant form of SMCD is spondylometaphyseal dysplasia Japanese type. It is characterized by spinal involvement comprising mild platyspondyly, vertebral body abnormalities, and end-plate irregularity. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Contains 1 C1q domain.

SWISS:
A1L4P2

Gene ID:
1300

Database links:

Entrez Gene: 282416 Cow

Entrez Gene: 1300 Human

Entrez Gene: 12813 Mouse

Entrez Gene: 25681 Rat

Omim: 120110 Human

SwissProt: P23206 Cow

SwissProt: A1L4P2 Human

SwissProt: Q03692 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Ⅹ型胶原是一种短链的非纤维性胶原，正常存在于软骨化骨中心及骨骺软骨生长板内，仅见于软骨细胞肥大区及钙化区前沿，在关节软骨见于钙化软骨层，由肥大软骨细胞特异表达，只短暂出现，可能参与软骨钙化的调节，是正常和异常骨形成的标志。
有学者认为：Ⅹ型胶原在骨性关节病中可作为软骨细胞表型不可逆转的诊断标志 ，是大量关节软骨细胞发生凋亡，最终导致关节软骨变薄，关节下骨变硬、增厚的主要原因。


















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