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CD34抗体
  • 产品货号：
    BN42168R
  • 中文名称：
    CD34抗体
  • 英文名称：
    Rabbit anti-CD34 Monoclonal antibody

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    产品规格

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  • BN42168R-50ul

    50ul

    ¥2020.00

    交叉反应：Rat,Mouse,Human(predicted:Dog) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN42168R-100ul

    100ul

    ¥3240.00

    交叉反应：Rat,Mouse,Human(predicted:Dog) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

英文名称CD34
中文名称CD34抗体
别    名CD34 antigen; CD34 molecule; Cluster designation 34; Hematopoietic progenitor cell antigen CD34; HPCA1; CD34_HUMAN.  
研究领域肿瘤  心血管  免疫学  发育生物学  神经生物学  干细胞  细胞表面分子  糖蛋白  细胞类型标志物  血管内皮细胞  内皮细胞  
抗体来源Rabbit
克隆类型Monoclonal
克 隆 号7A1
交叉反应Mouse,  (predicted: Human, Rat, Dog, )
产品应用ELISA=1:5000-10000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量39kDa
细胞定位细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原Recombinant human CD34: 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells, brain, and testis. Staining for CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence.

Function:
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.

Post-translational modifications:
Highly glycosylated.
Phosphorylated on serine residues by PKC.

Similarity:
Belongs to the CD34 family.

SWISS:
P28906

Gene ID:
947

Database links:

Entrez Gene: 947 Human

Omim: 142230 Human

SwissProt: P28906 Human

Unigene: 374990 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

造血干细胞标志物
内皮标志物
肿瘤生物标志物
细胞表面的唾液粘蛋白。
间充质干细胞（mesenchymal stem cells,MSC）也是干细胞家族的重要成员，来源于发育早期的中胚层和外胚层。MSC最初在骨髓中发现，因其具有多向分化潜能、造血支持和促进干细胞植入、免疫调控和自我复制等特点。如间充质干细胞在体内或体外特定的诱导条件下，可分化为血管内皮、脂肪、骨、软骨、肌肉、肌腱、韧带、神经、肝、心肌、等多种组织细胞。




















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