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着丝粒蛋白C1重组兔单克隆抗体
  • 产品货号：
    BN42165R
  • 中文名称：
    着丝粒蛋白C1重组兔单克隆抗体
  • 英文名称：
    Rabbit anti-CENPC1 Monoclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN42165R-50ul

    50ul

    ¥1820.00

    交叉反应（总）:Hu ;推荐应用:WB,

  • BN42165R-100ul

    100ul

    ¥2920.00

    交叉反应（总）:Hu ;推荐应用:WB,

英文名称CENPC1
中文名称着丝粒蛋白C1重组兔单克隆抗体
别    名CENP-C 1; CENP-C; CENPC_HUMAN; CENPC1; Centromere autoantigen C; Centromere autoantigen C1; Centromere protein C 1; ICEN7; Interphase centromere complex protein 7; MIF2.  
研究领域染色质和核信号  细胞周期蛋白  表观遗传学  
抗体来源Rabbit
克隆类型Monoclonal
克 隆 号3A7
交叉反应Human, 
产品应用WB=1:500-2000 IP=1:10-50 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量107kDa
细胞定位细胞核 
性    状Lyophilized or Liquid
浓    度1mg/ml
免 疫 原Recombinant human CENPC1 protein: 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12.

Function:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.

Subunit:
Oligomer. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Binds to DAXX. Interacts directly with CENPA.

Subcellular Location:
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres.

Similarity:
Belongs to the CENPC family.

SWISS:
Q03188

Gene ID:
1060

Database links:

Entrez Gene: 1060 Human

Omim: 117141 Human

SwissProt: Q03188 Human

Unigene: 479867 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.















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