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离子钙接头蛋白单克隆抗体
  • 产品货号：
    BN42155R
  • 中文名称：
    离子钙接头蛋白单克隆抗体
  • 英文名称：
    Rabbit anti-AIF1 (9A3) Monoclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN42155R-50ul

    50ul

    ¥2020.00

    交叉反应：Rat,Mouse,Human 推荐应用：WB,IHC-P,ICC,IF,Flow-Cyt

  • BN42155R-100ul

    100ul

    ¥3240.00

    交叉反应：Rat,Mouse,Human 推荐应用：WB,IHC-P,ICC,IF,Flow-Cyt

英文名称AIF1 (9A3)
中文名称离子钙接头蛋白单克隆抗体
别    名AIF 1; AIF1; AIF1 protein; IBa1; iba-1; IBa 1; allograft inflammatory factor 1; Allograft inflammatory factor 1 splice variant G; balloon angioplasty responsive transcription; BART 1; G1; G1 putative splice variant of allograft inflamatory factor 1; IBA 1; IBA1; interferon gamma responsive transcript; Ionized calcium binding adapter molecule 1; ionized calcium-binding adapter molecule; IRT 1; IRT1; Microglia response factor; MRF1; Protein G1.  
研究领域细胞生物  免疫学  神经生物学  
抗体来源Rabbit
克隆类型Monoclonal
克 隆 号9A3
交叉反应Human, Mouse, Rat, 
产品应用WB=1:500 IP=1:10-50 IHC-P=1:100-500 ICC=1:50-100 IF=1:50-100 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量17kDa
细胞定位细胞浆 细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human AIF1:100-147/147 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Allograft Inflammatory Factor-1 (AIF1)or ionized calcium-binding adaptor molecule 1 (Iba1) is expressed selectively in microglia/macrophages and is a Ca2+-binding peptide produced by activated monocytes and microglial cells. It has been suggested that AIF1 expression is associated with chronic inflammatory processes. AIF1 is expressed by activated monocytes and might participate in a variety of pathogenic processes in the mammalian brain and in chronic transplant rejection. It has been shown to be expressed early and persistently in chronically rejecting cardiac allografts but not in cardiac syngrafts and host hearts.

Function:
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.

Subunit:
Homodimer (Potential). Monomer. Interacts with LCP1.

Subcellular Location:
Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.

Tissue Specificity:
Detected in T-lymphocytes and peripheral blood mononuclear cells.

Similarity:
Contains 2 EF-hand domains.

SWISS:
P55008

Gene ID:
199

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.














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