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CD73重组兔单克隆抗体
  • 产品货号：
    BN42149R
  • 中文名称：
    CD73重组兔单克隆抗体
  • 英文名称：
    Rabbit anti-CD73 Monoclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN42149R-50ul

    50ul

    ¥2020.00

    交叉反应：Human 推荐应用：WB,IHC-P,IHC-F

  • BN42149R-100ul

    100ul

    ¥3240.00

    交叉反应：Human 推荐应用：WB,IHC-P,IHC-F

英文名称CD73
中文名称CD73重组兔单克隆抗体
别    名NT5; 5' NT; 5' nucleotidase (CD73); 5' nucleotidase precursor; 5' nucleotidase, ecto; 5' nucleotidase, ecto (CD73); 5'-NT; 5'-nucleotidase; 5'-nucleotidase; 5NTD_HUMAN; CD73; CD73 antigen; E5NT; Ecto 5' nucleotidase; Ecto-5'-nucleotidase; eN antibody eNT; NT antibody NT5; NT5E; NTE; Purine 5 Prime Nucleotidase.  
研究领域心血管  细胞生物  免疫学  细胞粘附分子  细胞表面分子  
抗体来源Rabbit
克隆类型Monoclonal
克 隆 号2C9
交叉反应Human, 
产品应用IHC-P=1:50-200 IHC-F=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量63kDa
细胞定位细胞膜 
性    状Lyophilized or Liquid
浓    度1mg/ml
免 疫 原Recombinant human CD73 protein: 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍CD73 is a glycosyl-phosphatidylinositol (GPI)-anchored adhesion protein that catalyzes the dephosphorylation of extracellular purine and pyrimidine nucleotides to their corresponding bioactive nucleosides. CD73 is a dimer of two identical subunits that depends on GPI to link with the external face of the plasma membrane. Similar to other GPI-anchored proteins, CD73 mediates co-stimulatory signals in T cell activation. CD73 has few structural variants, yet elicits diverse biological function through differential regulation in endothelial cells (EC), subpopulations of B and T cells, germinal center follicular dendritic cells and on thymic medullary reticular fibroblasts. For example, IgG mediated neutralization of CD73 interferes with lymphocyte adhesion to EC, and blocks aggregation of germinal center B cells and follicular dendritic cells. Furthermore, IgG-mediated targeting of lymphocyte CD73, but not of endothelial cell CD73, causes shedding of CD73 and tyrosine phosphorylation of proteins.

Function:
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.

Subcellular Location:
Cell membrane.

DISEASE:
Defects in NT5E are the cause of calcification of joints and arteries (CAJA). A condition characterized by adult-onset calcification of the lower extremity arteries, including the iliac, femoral and tibial arteries, and hand and foot capsule joints. Age of onset has been reported as early as the second decade of life, usually involving intense joint pain or calcification in the hands.

Similarity:
Belongs to the 5'-nucleotidase family.

SWISS:
P21589

Gene ID:
4907

Database links:

Entrez Gene: 4907 Human

Omim: 129190 Human

SwissProt: P21589 Human

Unigene: 153952 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
















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