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组织相容性复合体蛋白1重组兔单克隆抗体
  • 产品货号：
    BN42146R
  • 中文名称：
    组织相容性复合体蛋白1重组兔单克隆抗体
  • 英文名称：
    Rabbit anti-MHC class I Monoclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN42146R-50ul

    50ul

    ¥2020.00

    交叉反应：Human 推荐应用：WB,IHC-P

  • BN42146R-100ul

    100ul

    ¥3240.00

    交叉反应：Human 推荐应用：WB,IHC-P

英文名称MHC class I
中文名称组织相容性复合体蛋白1重组兔单克隆抗体
别    名MHC-1; MHC1; MHC 1; A 28; A 9; Aw 24; Aw 68; CLASS I HISTOCOMPATIBILITY ANTIGEN; H2 K1; H2K; HLA A; HLAA; HLA-A; HLA class I histocompatibility antigen A 1 alpha chain; HLA class I histocompatibility antigen A 11 alpha chain; HLA class I histocompatibility antigen A 2 alpha chain; HLA class I histocompatibility antigen A 24 alpha chain; HLA class I histocompatibility antigen A 3 alpha chain; HLA class I histocompatibility antigen A 30 alpha chain; HLA class I histocompatibility antigen A 32 alpha chain; HLA class I histocompatibility antigen A 68 alpha chain; Major histocompatibility complex class I A; MHC class I heavy chain H2 K; 1A24_HUMAN.  
研究领域肿瘤  细胞生物  免疫学  信号转导  转录调节因子  细胞分化  
抗体来源Rabbit
克隆类型Monoclonal
克 隆 号10G4
交叉反应Human, 
产品应用WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量40kDa
细胞定位细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human MHC class I: 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍MHC Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. MHC class I antigens are heterodimers consisting of one alpha chain (44kDa) with beta 2 microglobulin (11.5 kDa). The antigen is expressed by all somatic cells at varying levels. MHC Class I molecules are expressed on most nucleated cells where they present endogenously synthesized antigenic peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. Fibroblasts or neurons however only show a low level of antigen.

Function:
Involved in the presentation of foreign antigens to the immune system.

Subunit:
Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).

Subcellular Location:
Cell Membrane; Type I membrane protein.

Post-translational modifications:
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).

Similarity:
Belongs to the MHC class I family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

SWISS:
P05534

Gene ID:
3105

Database links:

Entrez Gene: 3105 Human

Omim: 142800 Human

SwissProt: P30443 Human

Unigene: 181244 Human 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.














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