核转录调节因子YY1 重组兔单克隆抗体

产品货号：

BN42127R
中文名称：

核转录调节因子YY1 重组兔单克隆抗体
英文名称：

Rabbit anti-YY1 Monoclonal antibody

货号

产品规格

售价

备注
BN42127R-50ul

50ul

¥2020.00

交叉反应：Human,Mouse,Rat 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt
BN42127R-100ul

100ul

¥3240.00

交叉反应：Human,Mouse,Rat 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt

产品描述

英文名称	YY1(Nuclear Loading Control)
中文名称	核转录调节因子YY1 （核内参）重组兔单克隆抗体
别名	Yin Yang 1; YY1 transcription factor; CF1; Delta; Delta transcription factor; NF E1; NFE1; Transcriptional repressor protein YY1; UCR motif DNA binding protein; UCRBP; Yin and yang 1; Yin Yang 1; Ying Yang 1; YY 1; YY 1 transcription factor; TYY1_HUMAN.
产品类型	内参抗体
研究领域	细胞生物染色质和核信号神经生物学信号转导细胞周期蛋白转录调节因子锌指蛋白表观遗传学
抗体来源	Rabbit
克隆类型	Monoclonal
克隆号	5F2
交叉反应	Human, Mouse, (predicted: Rat, )
产品应用	WB=1:500-2000 IP=1:20-100 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	46kDa
细胞定位	细胞核
性状	Liquid
浓度	1mg/ml
免疫原	Recombinant human YY1:
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	YY1 is a ubiquitously distributed transcription factor belonging to the GLI Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. Function: Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements. Subunit: Interacts with YAF2 through the region encompassing the first and second zinc fingers. Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Interacts with EED and EZH2; the interactions are indicative for an association with the PRC2/EED-EZH2 complex. Subcellular Location: Nucleus matrix. Note=Associated with the nuclear matrix. Post-translational modifications: Transiently poly-ADP-ribosylated by PARP1 upon DNA damage, with the effect of decreasing affinity of YY1 to its cognate DNA binding sites. Similarity: Belongs to the YY transcription factor family. Contains 4 C2H2-type zinc fingers. SWISS: P25490 Gene ID: 7528 Database links: Entrez Gene: 7528 Human Entrez Gene: 22632 Mouse Entrez Gene: 24919 Rat Omim: 600013 Human SwissProt: P25490 Human SwissProt: Q00899 Mouse Unigene: 388927 Human Unigene: 3868 Mouse Unigene: 458511 Mouse Unigene: 95861 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.