CD9重组兔单克隆抗体

产品货号：

BN42118R
中文名称：

CD9重组兔单克隆抗体
英文名称：

Rabbit anti-CD9 Monoclonal antibody

货号

产品规格

售价

备注
BN42118R-50ul

50ul

¥2020.00

交叉反应：Mouse,Human(predicted:Rat) 推荐应用：WB,IHC-P,IHC-F,ICC,ELISA
BN42118R-100ul

100ul

¥3240.00

交叉反应：Mouse,Human(predicted:Rat) 推荐应用：WB,IHC-P,IHC-F,ICC,ELISA

产品描述

英文名称	CD9
中文名称	CD9重组兔单克隆抗体
别名	Tetraspanin 29; 5H9; 5H9 antigen; Antigen defined by monoclonal; 602 29; Antigen defined by monoclonal; 60229; BA 2; BA2; BTCC 1; BTCC1; CD 9; CD9; CD9 antigen; CD9 antigen p24; CD9 molecule; CD9_HUMAN; Cell growth inhibiting gene 2 protein; Cell growth-inhibiting gene 2 protein; DRAP 27; DRAP27; GIG 2; GIG2; Growth inhibiting gene 2 protein; Leukocyte antigen MIC3; MIC 3; MIC3; Motility related protein; Motility-related protein; MRP 1; MRP-1; MRP1; p24; P24; p24 antigen; Tetraspanin 29; Tetraspanin-29; Tetraspanin29; Tspan 29; Tspan-29; Tspan29.
研究领域	肿瘤细胞生物免疫学发育生物学细胞表面分子
抗体来源	Rabbit
克隆类型	Monoclonal
克隆号	4C2
交叉反应	Human, Mouse, (predicted: Rat, )
产品应用	WB=1:500-1000 ELISA=1:5000-10000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	25kDa
细胞定位	细胞膜
性状	Lyophilized or Liquid
浓度	1mg/ml
免疫原	Recombinant human CD9 :
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed	PubMed
产品介绍	CD9 antigen is a glycoprotein expressed on the surface of developing B lymphocytes, platelets, monocytes, eosinophils, basophil, stimulated T lymphocytes and by neurons and glial cells in the peripheral nervous system. It belongs to a family of membrane proteins termed tetraspanins which transverse the membrane four times. In pre B cells and platelets, CD9 antigen regulates cell activation and aggregation possibly through an association with the integrin CD41 / CD61 (GPIIb / GPIIIa). It also regulates cell motility in a variety of cell lines, and appears to be an important regulator of Schwann cell behaviour in peripheral nerve. Function: Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion. Subunit: Forms both disulfide-linked homodimers and higher homooligomers as well as heterooligomers with other members of the tetraspanin family. Associates with CR2/CD21 and with PTGFRN/CD9P1. Interacts directly with IGSF8. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Expressed by a variety of hematopoietic and epithelial cells. Post-translational modifications: Protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids. Similarity: Belongs to the tetraspanin (TM4SF) family. SWISS: P21926 Gene ID: 928 Database links: Entrez Gene: 928 Human Entrez Gene: 12527 Mouse Entrez Gene: 24936 Rat Omim: 143030 Human SwissProt: P21926 Human SwissProt: P40240 Mouse SwissProt: P40241 Rat Unigene: 114286 Human Unigene: 210676 Mouse Unigene: 404614 Mouse Unigene: 2091 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CD9是一种普遍存在于细胞膜表面属于四跨膜超蛋白家族的细胞表面糖蛋白, 参与质膜的融合过程，在细胞膜生物学中发挥重要作用。近年来经研究发现，CD9与多种肿瘤转移有关，故称肿瘤转移抑制基因亦称抗肿瘤转移基因。是一个新的肿瘤转移抑制基因膜运动相关蛋白-1(CD9/MRP-1)，其分子功能还有待于进一步研究。CD9主要在早B细胞、活化T淋巴细胞、嗜酸性粒细胞、嗜碱性粒细胞和血小板表达。