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磷酸化GATA结合蛋白3重组兔单克隆抗体
  • 产品货号：
    BN42093R
  • 中文名称：
    磷酸化GATA结合蛋白3重组兔单克隆抗体
  • 英文名称：
    Rabbit anti-phospho-GATA3 (Ser308) Monoclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN42093R-50ul

    50ul

    ¥2020.00

    交叉反应：Human 推荐应用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt

  • BN42093R-100ul

    100ul

    ¥3240.00

    交叉反应：Human 推荐应用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt

英文名称phospho-GATA3 (Ser308)
中文名称磷酸化GATA结合蛋白3重组兔单克隆抗体
别    名GATA3 (phospho S308); p-GATA3 (phospho S308); GATA3 (phospho Ser308); p-GATA3 (Ser308); GATA 3; GATA3; GATA-3; GATA binding factor 3; GATA binding protein 3; HDR; MGC2346; MGC5199; MGC5445; Trans acting T cell specific transcription factor GATA 3; GATA3_HUMAN; Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3.  
产品类型磷酸化抗体 
研究领域肿瘤  细胞生物  发育生物学  神经生物学  信号转导  转录调节因子  t-淋巴细胞  
抗体来源Rabbit
克隆类型Monoclonal
克 隆 号3A1
交叉反应Human, 
产品应用WB=1:500-2000 IHC-P=1:50-200 IHC-F=1:50-200 Flow-Cyt=2ug/Test ICC=1:50-200 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量49kDa
细胞定位细胞核 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human GATA3 around the phosphorylation site of Ser308:RL(pS)AA  
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Members of the GATA family share a conserved zinc finger DNA-binding domain and are capable of binding the WGATAR consensus sequence. GATA-1 is erythroid-specific and is responsible for the regulated transcription of erythroid genes. It is an essential component in the generation of the erythroid lineage. GATA-2 is expressed in embryonic brain and liver, HeLa and endothelial cells, as well as in erythroid cells. Studies with a modified GATA consensus sequence, AGATCTTA, have shown that GATA-2 and GATA-3 recognize this mutated consensus while GATA-1 has poor recognition of this sequence. This indicates broader regulatory capabilities of GATA-2 and GATA-3 than GATA-1. GATA-3 is highly expressed in T lymphocytes. GATA-4, GATA-5 and GATA-6 comprise a subfamily of transcription factors. Both GATA-4 and GATA-6 are found in heart, pancreas and ovary; lung and liver tissues exhibit GATA-6, but not GATA-4 expression. GATA-5 expression has been observed in differentiated heart and gut tissues and is present throughout the course of development in the heart. Although expression patterns of the various GATA transcription factors may overlap, it is not yet apparent how the GATA factors are able to discriminate in binding their appropriate target sites.

Function:
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'.

Subcellular Location:
Nucleus.

Tissue Specificity:
T-cells and endothelial cells.

DISEASE:
Defects in GATA3 are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia (HDR) [MIM:146255]; also known as Barakat syndrome.

Similarity:
Contains 2 GATA-type zinc fingers.

SWISS:
P23771

Gene ID:
2625

Database links:

Entrez Gene: 2625 Human

Entrez Gene: 14462 Mouse

Entrez Gene: 85471 Rat

Omim: 131320 Human

SwissProt: P23771 Human

SwissProt: P23772 Mouse

Unigene: 524134 Human

Unigene: 313866 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
















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