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BN42063M-50ul
50ul
¥2020.00
交叉反应：Human,Mouse 推荐应用：WB,IHC-P,IHC-F,IF
BN42063M-100ul
100ul
¥3240.00
交叉反应：Human,Mouse 推荐应用：WB,IHC-P,IHC-F,IF
| 英文名称 | SOD2 |
| 中文名称 | 超氧化物歧化酶2单克隆抗体 |
| 别 名 | IPO B; Manganese SOD; Superoxide Dismutase 2; Manganese superoxide dismutase; Mn SOD; MNSOD; SOD 2; SOD-2; SOD2; Superoxide dismutase [Mn] mitochondrial; Superoxide dismutase [Mn] mitochondrial precursor; Superoxide dismutase 2 mitochondrial; SODM_HUMAN. |
| 研究领域 | 神经生物学 细胞凋亡 激酶和磷酸酶 线粒体 |
| 抗体来源 | Mouse |
| 克隆类型 | Monoclonal |
| 克 隆 号 | 6C11 |
| 交叉反应 | Human, Mouse, |
| 产品应用 | WB=1:200-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:20-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 22kDa |
| 细胞定位 | 细胞浆 线粒体 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | Recombinant human SOD protein: |
| 亚 型 | IgG1κ |
| 纯化方法 | affinity purified by Protein G |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Function: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Subunit: Homotetramer. Subcellular Location: Mitochondrion matrix. Post-translational modifications: Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity. Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting. DISEASE: Microvascular complications of diabetes 6 (MVCD6) [MIM:612634]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Similarity: Belongs to the iron/manganese superoxide dismutase family. SWISS: P04179 Gene ID: 6648 Database links: Entrez Gene: 374042 Chicken Entrez Gene: 6648 Human Entrez Gene: 20656 Mouse Omim: 147460 Human SwissProt: P04179 Human SwissProt: P09671 Mouse SwissProt: P41982 Rabbit Unigene: 487046 Human Unigene: 290876 Mouse Unigene: 10488 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
