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CD34单克隆抗体
  • 产品货号：
    BN42053M
  • 中文名称：
    CD34单克隆抗体
  • 英文名称：
    Mouse anti-CD34 Monoclonal antibody

  • 货号

    产品规格

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  • BN42053M-50ul

    50ul

    ¥1486.00

    交叉反应：Human 推荐应用：WB,IHC-F,IF,ELISA

  • BN42053M-100ul

    100ul

    ¥2360.00

    交叉反应：Human 推荐应用：WB,IHC-F,IF,ELISA

英文名称CD34
中文名称CD34单克隆抗体
别    名CD34 antigen; CD34 molecule; Cluster designation 34; Hematopoietic progenitor cell antigen CD34; HPCA1; CD34_HUMAN; Hematopoietic Stem Cell Marker; Endothelial Markers; Tumor biomarkers.  
研究领域肿瘤  心血管  细胞生物  干细胞  细胞粘附分子  细胞表面分子  糖蛋白  血管内皮细胞  
抗体来源Mouse
克隆类型Monoclonal
克 隆 号5B4
交叉反应Human, 
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量39kDa
细胞定位细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原Recombinant human CD34 :32-290/385 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells, brain, and testis. Staining for CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence.
Hematopoietic Stem Cell Marker
Endothelial Markers
Tumor biomarkers


Function:
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.

Post-translational modifications:
Highly glycosylated.
Phosphorylated on serine residues by PKC.

Similarity:
Belongs to the CD34 family.

SWISS:
P28906

Gene ID:
947

Database links:

Entrez Gene: 947 Human

Omim: 142230 Human

SwissProt: P28906 Human

Unigene: 374990 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


















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