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葡萄糖调节蛋白78单克隆抗体
  • 产品货号：
    BN42025M
  • 中文名称：
    葡萄糖调节蛋白78单克隆抗体
  • 英文名称：
    Mouse anti-GRP78/Bip Monoclonal antibody

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    产品规格

    售价

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  • BN42025M-50ul

    50ul

    ¥1486.00

    交叉反应：Human(predicted:Rat) 推荐应用：WB,IHC-P,IHC-F,ICC,IF

  • BN42025M-100ul

    100ul

    ¥2360.00

    交叉反应：Human(predicted:Rat) 推荐应用：WB,IHC-P,IHC-F,ICC,IF

英文名称GRP78/Bip
中文名称葡萄糖调节蛋白78单克隆抗体
别    名BIP; HSPA5; glucose regulated protein 78; 78 kDa glucose regulated protein; BIP; Endoplasmic reticulum lumenal Ca2+ binding protein grp78; FLJ26106; Glucose Regulated Protein 78kDa; GRP 78; GRP78; Heat Shock 70kDa Protein 5; HSPA 5; HSPA-5; HSPA5; Immunoglobulin Heavy Chain Binding Protein; MIF2; GRP78_HUMAN.  
研究领域肿瘤  细胞生物  免疫学  
抗体来源Mouse
克隆类型Monoclonal
克 隆 号10A3
交叉反应Human,  (predicted: Rat, )
产品应用WB=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量78kDa
细胞定位细胞浆 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human GRP78/Bip: 
亚    型IgG
纯化方法affinity purified by Protein G
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍The 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shock proteins (HSP 70). GRP78 is a resident protein of the endoplasmic reticulum (ER) and may associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP 94) and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.

Function:
Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

Subcellular Location:
Endoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

DISEASE:
Note=Autoantigen in rheumatoid arthritis.

Similarity:
Belongs to the heat shock protein 70 family.

SWISS:
P11021

Gene ID:
3309

Database links:

Entrez Gene: 3309 Human

Entrez Gene: 14828 Mouse

Entrez Gene: 25617 Rat

Omim: 138120 Human

SwissProt: P11021 Human

SwissProt: P20029 Mouse

SwissProt: P06761 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

葡萄糖调节蛋白78是热休克蛋白70家族的成员之一又称：热休克蛋白70蛋白5,作为一种分子伴侣在蛋白质的折叠和转运过程及内质网应激反应中发挥重要作用.它在多种肿瘤组织中呈高表达.

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