丝裂原活化蛋白激酶激酶2单克隆抗体

产品货号：

BN42021M
中文名称：

丝裂原活化蛋白激酶激酶2单克隆抗体
英文名称：

Mouse anti-MEK2 Monoclonal antibody

货号

产品规格

售价

备注
BN42021M-50ul

50ul

¥1486.00

交叉反应：Human,Mouse,Rat 推荐应用：WB,IHC-P,IHC-F,ICC,IF
BN42021M-100ul

100ul

¥2360.00

交叉反应：Human,Mouse,Rat 推荐应用：WB,IHC-P,IHC-F,ICC,IF

产品描述

英文名称	MEK2
中文名称	丝裂原活化蛋白激酶激酶2单克隆抗体
别名	Cardiofaciocutaneous syndrome; CFC syndrome; Dual specificity mitogen activated protein kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; FLJ26075; MAP kinase kinase 2; MAP2K 2; map2k2; MAPK / ERK kinase 2; MAPK/ERK kinase 2; MAPKK 2; MAPKK2; MEK 2; MEK2; Microtubule Associated Protein Kinase Kinase 2; Mitogen activated protein kinase kinase 2; Mitogen activated protein kinase kinase 2 p45; MKK 2; MKK2; MP2K2_HUMAN; OTTHUMP00000165826; OTTHUMP00000165827; PRKMK 2; PRKMK2 V.
研究领域	肿瘤细胞生物免疫学神经生物学信号转导激酶和磷酸酶
抗体来源	Mouse
克隆类型	Monoclonal
克隆号	4C3
交叉反应	Human, Mouse, Rat,
产品应用	WB=1:1000-2000 IHC-P=1:200-1000 IHC-F=1:200-1000 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	46kDa
细胞定位	细胞浆
性状	Liquid
浓度	1mg/ml
免疫原	Recombinant human MEK2 Protein:1-171/400
亚型	IgG
纯化方法	affinity purified by Protein G
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]. Function: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases. Subunit: Interacts with MORG1. Interacts with SGK1. Post-translational modifications: MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1). Phosphorylated by MAP2K1/MEK1. Acetylation of Ser-222 and Ser-226 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway. DISEASE: Defects in MAP2K2 are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant. Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. Contains 1 protein kinase domain. SWISS: P36507 Gene ID: 5605 Database links: Entrez Gene: 407835 Human Entrez Gene: 5605 Human Entrez Gene: 26396 Mouse Entrez Gene: 58960 Rat Omim: 601263 Human SwissProt: P36507 Human SwissProt: Q63932 Mouse SwissProt: P36506 Rat Unigene: 465627 Human Unigene: 275436 Mouse Unigene: 82693 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 丝裂原活化蛋白激酶激酶(MAPKK)是信号转导途径中的重要成员。