Catalog Number: BN42019M 

Target Protein: TNF alpha 

Concentration: 1mg/ml 

Form: Size : 50ul/100ul

           Liquid Size : 200ug (PBS only) 

           Lyophilized Note: Centrifuge tubes before opening. Reconstitute the lyophilized product in distilled water. Optimal concentration should be determined by the end user. 

Host: Mouse 

Clonality: Monoclonal 

Clone No.: 3A4 

Isotype: IgG1 

Applications: WB (1:1000-2000), IHC-P (1:100-500), IHC-F (1:200-500), ICC/IF (1:100-500), IF (1:200-500), ELISA (1:5000-10000) 

Reactivity: Rat (predicted:Mouse,Rabbit,Pig,Sheep,Cow,Chicken,Dog,GuineaPig,Monkey) 

Predicted MW: 17/26 kDa 

Entrez Gene: 7124

Swiss Prot: P01375 

Purification: affinity purified by Protein G 

Storage: Size : 50ul/100ul

              0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. 

              Size : 200ug (PBS only) 0.01M PBS Shipped at 4℃. 

              Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. 

Background: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affectsusceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine