细胞角蛋白18单克隆抗体

产品货号：

BN41998M
中文名称：

细胞角蛋白18单克隆抗体
英文名称：

Mouse anti-CK18 Monoclonal antibody

货号

产品规格

售价

备注
BN41998M-50ul

50ul

¥1486.00

交叉反应：Rat,Mouse,Human 推荐应用：WB,IHC-P,IHC-F,ICC,IF
BN41998M-100ul

100ul

¥2360.00

交叉反应：Rat,Mouse,Human 推荐应用：WB,IHC-P,IHC-F,ICC,IF

产品描述

英文名称	CK18
中文名称	细胞角蛋白18单克隆抗体
别名	Cell proliferation inducing gene 46 protein; Cell proliferation inducing protein 46; CK 18; CK18; CYK18; Cytokeratin 18; Cytokeratin endo B; Cytokeratin18; Keratin 18; Keratin D; Keratin type I cytoskeletal 18; Kerd; KRT18.
研究领域	肿瘤细胞生物免疫学信号转导
抗体来源	Mouse
克隆类型	Monoclonal
克隆号	10H2
交叉反应	Human, Mouse,
产品应用	WB=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	48kDa
细胞定位	细胞浆细胞膜
性状	Liquid
浓度	1mg/ml
免疫原	Recombinant human CK18 peptide:
亚型	IgG
纯化方法	affinity purified by Protein G
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]. Function: When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. Post-translational modifications: Phosphorylation increases by IL-6. Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-231 by either caspase-3, caspas-6 or caspase-7. O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residue. Similarity: Belongs to the intermediate filament family. SWISS: P05783 Gene ID: 3875 Database links: Entrez Gene: 506480 Cow Entrez Gene: 3875 Human Entrez Gene: 16668 Mouse Entrez Gene: 294853 Rat Omim: 148070 Human SwissProt: P05783 Human SwissProt: P05784 Mouse SwissProt: Q5BJY9 Rat Unigene: 406013 Human Unigene: 22479 Mouse Unigene: 103924 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 结构蛋白（Structural Proteins）常用于肿瘤细胞的分化、增殖及转移方面的研究。