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FK506结合蛋白38抗体
  • 产品货号：
    BN41960R
  • 中文名称：
    FK506结合蛋白38抗体
  • 英文名称：
    Rabbit anti-FKBP38 Polyclonal antibody

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  • BN41960R-50ul

    50ul

    ¥1486.00

    交叉反应：Mouse,Rat(predicted:Human,Chicken,Dog,Cow,Horse) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41960R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse,Rat(predicted:Human,Chicken,Dog,Cow,Horse) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41960R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse,Rat(predicted:Human,Chicken,Dog,Cow,Horse) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

英文名称FKBP38
中文名称FK506结合蛋白38抗体
别    名38 kDa FK 506 binding protein homolog; 38 kDa FK506-binding protein; 38 kDa FKBP; 38kDa antibody FK506 binding protein 8; FK506 binding protein 8, 38kDa; FK506 binding protein, 38kDa; FK506-binding protein 8; FKBP 38; FKBP-38; FKBP-8; FKBP8; FKBP8_HUMAN; FKBPR38; hFKBP38; Peptidyl-prolyl cis-trans isomerase FKBP8; PPIase FKBP8; Rotamase; Sam11.  
研究领域细胞生物  免疫学  信号转导  细胞凋亡  转录调节因子  结合蛋白  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,  (predicted: Human, Chicken, Dog, Cow, Horse, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量46kDa
细胞定位细胞浆 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human FKBP38:255-350/412 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.
Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation.
Tissue specificity: Widely expressed. Highest levels seen in the brain.

Function:
Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.

Subunit:
Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation.

Subcellular Location:
Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side (By similarity).

Tissue Specificity:
Widely expressed. Highest levels seen in the brain.

Similarity:
Contains 1 PPIase FKBP-type domain.
Contains 3 TPR repeats.

SWISS:
Q14318

Gene ID:
23770

Database links:

Entrez Gene: 23770 Human

Entrez Gene: 14232 Mouse

Entrez Gene: 290652 Rat

Omim: 604840 Human

SwissProt: Q14318 Human

SwissProt: O35465 Mouse

SwissProt: Q3B7U9 Rat

Unigene: 173464 Human

Unigene: 141864 Mouse

Unigene: 99789 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.



















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