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叉头相关转录因子3/FOXC1抗体
  • 产品货号：
    BN41947R
  • 中文名称：
    叉头相关转录因子3/FOXC1抗体
  • 英文名称：
    Rabbit anti-FREAC3 Polyclonal antibody

  • 货号

    产品规格

    售价

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  • BN41947R-50ul

    50ul

    ¥1486.00

    交叉反应：Rat,Mouse,Human(predicted:Horse,Cow,Dog,Chicken) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41947R-100ul

    100ul

    ¥2360.00

    交叉反应：Rat,Mouse,Human(predicted:Horse,Cow,Dog,Chicken) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41947R-200ul

    200ul

    ¥3490.00

    交叉反应：Rat,Mouse,Human(predicted:Horse,Cow,Dog,Chicken) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

英文名称FREAC3
中文名称叉头相关转录因子3/FOXC1抗体
别    名ARA; FKH L7; FKHL 7; FKHL7; Forkhead (Drosophila) like 7; Forkhead; forkhead box C1; Forkhead box protein C1; Forkhead drosophila homolog like 7; Forkhead like 7; Forkhead related activator 3; Forkhead related protein FKHL7; Forkhead related transcription factor 3; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; FOX C1; FOXC 1; FOXC1; FOXC1_HUMAN; FREAC 3; FREAC-3; FREAC3; homolog-like 7; IGDA; IHG 1; IHG1; IRID 1; IRID1; Iridogoniodysgenesis type 1; Myeloid factor delta.  




研究领域细胞生物  发育生物学  转录调节因子  表观遗传学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,  (predicted: Chicken, Dog, Cow, Horse, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/test IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量57kDa
细胞定位细胞核 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human FOXC1/FREAC3:101-200/553 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees.
Involvement in disease; Defects in FOXC1 are the cause of Axenfeld-Rieger syndrome type 3 (RIEG3); also known as Axenfeld-Rieger syndrome (ARS) or Axenfeld syndrome or Axenfeld anomaly. It is characterized by posterior corneal embryotoxon, prominent Schwalbe line and iris adhesion to the Schwalbe line. Other features may be hypertelorism (wide spacing of the eyes), hypoplasia of the malar bones, congenital absence of some teeth and mental retardation. When associated with tooth anomalies, the disorder is known as Rieger syndrome. Glaucoma is a progressive blinding condition that occurs in approximately half of patients with Axenfeld-Rieger malformations.

Function:
Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees.

Subunit:
Monomer.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in all tissues and cell lines examined.

DISEASE:
Defects in FOXC1 are the cause of iridogoniodysgenesis anomaly (IGDA) [MIM:601631]. IGDA is an autosomal dominant phenotype characterized by iris hypoplasia, goniodysgenesis, and juvenile glaucoma.
[DISEASE] Defects in FOXC1 are a cause of Peters anomaly (PAN) [MIM:604229]. Peters anomaly consists of a central corneal leukoma, absence of the posterior corneal stroma and Descemet membrane, and a variable degree of iris and lenticular attachments to the central aspect of the posterior cornea.


Similarity:
Contains 1 fork-head DNA-binding domain.

SWISS:
Q12948

Gene ID:
2296

Database links:

Entrez Gene: 2296 Human

Entrez Gene: 17300 Mouse

GenBank: NP_001444 Human

Omim: 601090 Human

SwissProt: Q12948 Human

SwissProt: Q61572 Mouse

SwissProt: Q32NP8 Xenopus laevis

Unigene: 348883 Human

Unigene: 12949 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.



















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