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BN41935R-50ul
50ul
¥1486.00
交叉反应：Human,Mouse,Rat(predicted:Dog,Horse) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41935R-100ul
100ul
¥2360.00
交叉反应：Human,Mouse,Rat(predicted:Dog,Horse) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN41935R-200ul
200ul
¥3490.00
交叉反应：Human,Mouse,Rat(predicted:Dog,Horse) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
| 英文名称 | WNT4 |
| 中文名称 | 信号通路Wnt4抗体 |
| 别 名 | WNT4_HUMAN; Protein Wnt-4. |
| 研究领域 | 肿瘤 细胞生物 免疫学 染色质和核信号 细胞周期蛋白 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, (predicted: Dog, Horse, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 细胞定位 | 细胞外基质 分泌型蛋白 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human WNT4:201-300/351 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue. Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue. Subunit: Interacts with PORCN. Subcellular Location: Secreted, extracellular space, extracellular matrix. DISEASE: Defects in WNT4 are a cause of Rokitansky-Kuster-Hauser syndrome (RKH syndrome) [MIM:277000]; also called Mayer-Rokitansky-Kuster-Hauser syndrome (MRKH syndrome or MRKH anomaly). RKH syndrome is characterized by utero-vaginal atresia in otherwise phenotypically normal female with a normal 46,XX karyotype. Anomalies of the genital tract range from upper vaginal atresia to total Muellerian agenesis with urinary tract abnormalities. It has an incidence of approximately 1 in 5'000 newborn girls. Defects in WNT4 are the cause of female sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL) [MIM:611812]; also known as SERKAL syndrome. Defects in WNT4 are the cause of Muellerian aplasia (MULLAPL) [MIM:158330]. Similarity: Belongs to the Wnt family. SWISS: P56705 Gene ID: 54361 Database links: Entrez Gene: 54361 Human Entrez Gene: 22417 Mouse Omim: 603490 Human SwissProt: P56705 Human SwissProt: P22724 Mouse Unigene: 25766 Human Unigene: 611722 Human Unigene: 20355 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
