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激肽释放酶8抗体
  • 产品货号：
    BN41927R
  • 中文名称：
    激肽释放酶8抗体
  • 英文名称：
    Rabbit anti-KLK8 Polyclonal antibody

  • 货号

    产品规格

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  • BN41927R-50ul

    50ul

    ¥1486.00

    交叉反应：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,GuineaPig) 推荐应用：IHC-P,IHC-F,IF,ELISA

  • BN41927R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,GuineaPig) 推荐应用：IHC-P,IHC-F,IF,ELISA

  • BN41927R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,GuineaPig) 推荐应用：IHC-P,IHC-F,IF,ELISA

英文名称KLK8
中文名称激肽释放酶8抗体
别    名Kallikrein-8; Ovasin; Serine protease TADG 14; Tumor associated differentially expressed gene 14 protein; Brain serine protease 1; BSP1; hK8; HNP; HPN; Kallikrein 8 (neuropsin/ovasin); Kallikrein related peptidase 8; Kallikrein8; KLK 8; KLK8; KLK-8; KLK8 protein type 1; KLK8 protein type 2; Neuropsin; neuropsin type 1; Neuropsin type 1, included; Neuropsin type 2; Neuropsin type 2, included; Neuropsin, mouse, homolog of; NP; NRPN; Protease serine 19; PRSS 19; PRSS19; Serine protease 19; Serine protease kallikrein; Serine protease kallikrein/ovasin/neuropsin; Serine protease TADG14; TADG 14; TADG14; Tumor associated differentially expressed gene 14.  


研究领域肿瘤  细胞生物  免疫学  信号转导  细胞粘附分子  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,  (predicted: Human, Dog, Pig, Cow, Horse, Guinea Pig, )
产品应用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:200-800 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量28kDa
细胞定位细胞浆 分泌型蛋白 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human KLK8:51-150/260 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Kallikrein 8 (hK8), also known as neuropsin, brain serine protease 1 (BSP1), tumor associated differentially expressed gene 14 (TADG14), PRSS19, HNP and ovasin, is a trypsin like serine protease. Originally described from mouse brain, KLK8 was implicated in neural plasticity and learning. Kallikrein 8 is thought to be involved in neurite outgrowth and fasciculation during nervous system development. Kallikrein 8 is induced in neurite injury, and Kallikrein 8 has been shown to be elevated in the hippocampus on Alzheimer’s patients’ brains. Animal models of autoimmune encephalomyelitis (EAE) show elevated Kallikrein 8 production. Kallikrein 8 null mice have aberrant synapses in their hippocampus, compared to wild type mice, and are predisposed to seizures. Kallikrein 8 is thought to regulate the early phase of long-term potentiation (LTP), possibly by cleaving fibronectin and other substrates. Kallikrein 8 is also found in the uterus, where it is hormonally regulated. Cervical cancer cell lines express high levels of Kallikrein 8, and it may be useful as a tumor marker. Kallikrein 8 is not limited to the brain and uterus, as many tissues and cell lines make the protein. Endogenous inhibitors include serine protease inhibitor 3 and protein C inhibitor, although Kallikrein 8 can be found complexed to a number of different protease inhibitors.

Subcellular Location:
Secreted. Cytoplasm. Shows a cytoplasmic distribution in the keratinocytes.

Tissue Specificity:
Isoform 1 is predominantly expressed in the pancreas. Isoform 2 is expressed in adult brain and hippocampus. Isoform 1 and isoform 2 are found in fetal brain and placenta. Detected in salivary gland, uterus, thymus, breast, testis and kidney but not in spleen, liver, lung or normal ovarian tissue. Displays an 11.5-fold increase in Alzheimer disease hippocampus compared to controls and is overexpressed in some ovarian carcinomas. Expressed at low levels in normal skin while high levels are found in psoriasis vulgaris, seborrheic keratosis, lichen planus and squamous cell carcinoma skin samples. Expressed in the keratinocytes.

Similarity:
Belongs to the peptidase S1 family. Kallikrein subfamily.

SWISS:
Q61955

Gene ID:
11202

Database links:

Entrez Gene: 11202 Human

Omim: 605644 Human

SwissProt: O60259 Human

Unigene: 104570 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

细胞外基质蛋白


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