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BN41911R-50ul
50ul
¥1486.00
交叉反应：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Sheep) 推荐应用：WB,IHC-P,Flow-Cyt,ELISA
BN41911R-100ul
100ul
¥2360.00
交叉反应：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Sheep) 推荐应用：WB,IHC-P,Flow-Cyt,ELISA
BN41911R-200ul
200ul
¥3490.00
交叉反应：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Sheep) 推荐应用：WB,IHC-P,Flow-Cyt,ELISA
| 英文名称 | GDF9 |
| 中文名称 | 生长分化因子9抗体 |
| 别 名 | GDF9_HUMAN; GDF9; GDF-9; GDF 9; Growth differentiation factor 9. |
| 研究领域 | 心血管 免疫学 信号转导 干细胞 生长因子和激素 细胞分化 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, (predicted: Chicken, Dog, Pig, Cow, Horse, Sheep, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=1ug/Test （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 15kDa |
| 细胞定位 | 分泌型蛋白 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GDF9:301-400/454 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | GDF 9 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell synthesized by ovarian somatic cells directly affect oocyte growth and function. GDF 9 is expressed in oocytes and is thought to be required for ovarian folliculogenesis. Function: Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells. Subunit: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked (By similarity). Subcellular Location: Secreted (By similarity). Tissue Specificity: Expressed in ovarian granulosa cells. Present in oocytes of primary follicles (at protein level). Post-translational modifications: Phosphorylated; phosphorylation is critical for GDF9 function. In vitro, can be phosphorylated by CK at Ser-325. DISEASE: Note=Altered GDF9 function may be involved in ovarian disorders. Rare variants in GDF9 have been found in patients with premature ovarian failure and mothers of dizygotic twins. Similarity: Belongs to the TGF-beta family. SWISS: O60383 Gene ID: 2661 Database links: Entrez Gene: 2661 Human Entrez Gene: 14566 Mouse Omim: 601918 Human SwissProt: O60383 Human SwissProt: Q07105 Mouse Unigene: 25022 Human Unigene: 490461 Mouse Unigene: 9714 Mouse Unigene: 42874 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. GDF9属于转移生长因子–β(TGF-β)及骨形态发生蛋白（BMP）家族成员。 |
