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谷氨酰胺合成酶/谷氨酸氨连接酶抗体
  • 产品货号：
    BN41893R
  • 中文名称：
    谷氨酰胺合成酶/谷氨酸氨连接酶抗体
  • 英文名称：
    Rabbit anti-Glutamine synthetase Polyclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN41893R-50ul

    50ul

    ¥1486.00

    交叉反应：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41893R-100ul

    100ul

    ¥2360.00

    交叉反应：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41893R-200ul

    200ul

    ¥3490.00

    交叉反应：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

英文名称Glutamine synthetase
中文名称谷氨酰胺合成酶/谷氨酸氨连接酶抗体
别    名cell proliferation-inducing protein 59; GLNA; GLNA_HUMAN; GLNS; GLUL; Glutamate ammonia ligase; Glutamate decarboxylase; Glutamate--ammonia ligase; glutamine synthase; Glutamine synthetase; GS; PIG 43; PIG 59; PIG43; PIG59; Proliferation inducing protein 43.  
研究领域免疫学  神经生物学  信号转导  线粒体  Alzheimer's  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量42kDa
细胞定位细胞浆 线粒体
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Glutamine synthetase:285-373/373 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Glutamine Synthetase catalyzes the conversion of ammonia and glutamate to glutamine. It is found in astrocytes as an octamer of identical 42 kDa subunits. The function of Glutamine Synthetase is the detoxification of brain ammonia. It also has an important role in the metabolic regulation of neurotransmitter glutamate. Because of the multiple functions and importance of Glutamine Synthetase in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of Glutamine Synthetase is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer's disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation. The level of expression of Glutamine Synthetase is increased during ischemia in vivo or hypoxia in culture.

Function:
This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts.

Subcellular Location:
Cytoplasm. Mitochondrion.

DISEASE:
Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD) [MIM:610015]. CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid.

Similarity:
Belongs to the glutamine synthetase family.

SWISS:
P15104

Gene ID:
2752

Database links:

Entrez Gene: 2752 Human

Entrez Gene: 281199 Cow

Entrez Gene: 403443 Dog

Entrez Gene: 14645 Mouse

Entrez Gene: 24957 Rat

Omim: 138290 Human

SwissProt: P15103 Cow

SwissProt: Q8HZM5 Dog

SwissProt: P15104 Human

SwissProt: P15105 Mouse

SwissProt: P09606 Rat

Unigene: 518525 Human

Unigene: 210745 Mouse

Unigene: 2204 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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