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糖蛋白gp330抗体
  • 产品货号：
    BN41883R
  • 中文名称：
    糖蛋白gp330抗体
  • 英文名称：
    Rabbit anti-Megalin Polyclonal antibody

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    产品规格

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  • BN41883R-50ul

    50ul

    ¥1486.00

    交叉反应：Mouse,Human(predicted:Rabbit,Horse,Dog,Chicken,Rat) 推荐应用：IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41883R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse,Human(predicted:Rabbit,Horse,Dog,Chicken,Rat) 推荐应用：IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41883R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse,Human(predicted:Rabbit,Horse,Dog,Chicken,Rat) 推荐应用：IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

英文名称Megalin
中文名称糖蛋白gp330抗体
别    名Calcium sensor protein; DBS; Glycoprotein 330; gp330; Heymann nephritis antigen homolog; Low-density lipoprotein receptor-related protein 2; LRP-2; Lrp2; LRP2_HUMAN.  


研究领域肿瘤  细胞生物  免疫学  糖尿病  糖蛋白  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse,  (predicted: Rat, Chicken, Dog, Horse, Rabbit, )
产品应用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=3ug/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量519kDa
细胞定位细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Lrp2/Megalin:3401-3500/4655 <Extracellular>
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009].

Function:
Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release.

Subunit:
Binds plasminogen, extracellular matrix components, plasminogen activator-plasminogen activator inhibitor type I complex, apolipoprotein E-enriched beta-VLDL, lipoprotein lipase, lactoferrin, CLU/clusterin and calcium. Forms a multimeric complex together with a receptor-associated protein (RAP). Binds to ankyrin-repeat family A protein 2 (ANKRA2). Interacts with LRP2BP.

Subcellular Location:
Membrane; Single-pass type I membrane protein. Membrane, coated pit.

Tissue Specificity:
Absorptive epithelia, including renal proximal tubules.

DISEASE:
Defects in LRP2 are the cause of Donnai-Barrow syndrome (DBS) [MIM:222448]; also known as faciooculoacousticorenal syndrome (FOAR syndrome). DBS is a rare autosomal recessive disorder characterized by major malformations including agenesis of the corpus callosum, congenital diaphragmatic hernia, facial dysmorphology, ocular anomalies, sensorineural hearing loss and developmental delay. The FOAR syndrome was first described as comprising facial anomalies, ocular anomalies, sensorineural hearing loss, and proteinuria. DBS and FOAR were first described as distinct disorders but the classic distinguishing features between the 2 disorders were presence of proteinuria and absence of diaphragmatic hernia and corpus callosum anomalies in FOAR. Early reports noted that the 2 disorders shared many phenotypic features and may be identical. Although there is variability in the expression of some features (e.g. agenesis of the corpus callosum and proteinuria), DBS and FOAR are now considered to represent the same entity.

Similarity:
Belongs to the LDLR family.
Contains 17 EGF-like domains.
Contains 36 LDL-receptor class A domains.
Contains 37 LDL-receptor class B repeats.

SWISS:
P98164

Gene ID:
4036

Database links:

Entrez Gene: 4036 Human

Entrez Gene: 14725 Mouse

Entrez Gene: 29216 Rat

Omim: 600073 Human

SwissProt: P98164 Human

SwissProt: A2ARV4 Mouse

SwissProt: P98158 Rat

Unigene: 657729 Human

Unigene: 23847 Mouse

Unigene: 26430 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Lrp2属于低密度脂蛋白受体家族成员，是肾小管重吸收白蛋白的重要受体蛋白。


























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