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硫氧还蛋白结合蛋白2抗体
  • 产品货号：
    BN41882R
  • 中文名称：
    硫氧还蛋白结合蛋白2抗体
  • 英文名称：
    Rabbit anti-TXNIP Polyclonal antibody

  • 货号

    产品规格

    售价

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  • BN41882R-50ul

    50ul

    ¥1486.00

    交叉反应：Human,Rat(predicted:Mouse,Dog,Pig,Rabbit) 推荐应用：IHC-P,IHC-F,IF,ELISA

  • BN41882R-100ul

    100ul

    ¥2360.00

    交叉反应：Human,Rat(predicted:Mouse,Dog,Pig,Rabbit) 推荐应用：IHC-P,IHC-F,IF,ELISA

  • BN41882R-200ul

    200ul

    ¥3490.00

    交叉反应：Human,Rat(predicted:Mouse,Dog,Pig,Rabbit) 推荐应用：IHC-P,IHC-F,IF,ELISA

英文名称TXNIP
中文名称硫氧还蛋白结合蛋白2抗体
别    名;THIF; thioredoxin binding protein 2; thioredoxin interacting protein; Thioredoxin-binding protein 2; Thioredoxin-interacting protein; upregulated by 1,25-dihydroxyvitamin D-3; VDUP1; Vitamin D3 up-regulated protein 1; TXNIP_HUMAN. 


研究领域肿瘤  免疫学  转录调节因子  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Rat,  (predicted: Mouse, Dog, Pig, Rabbit, )
产品应用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/test IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量44kDa
细胞定位细胞核 细胞浆 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human TXNIP:101-200/391 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. It interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. It functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. It is required for the maturation of natural killer cells (from SwissProt).

Function:
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).

Subunit:
Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4.

Subcellular Location:
Cytoplasm

Post-translational modifications:
Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.

Similarity:
Belongs to the arrestin family.

SWISS:
Q9H3M7

Gene ID:
10628

Database links:
UniProtKB/Swiss-Prot: Q9H3M7.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    硫氧还蛋白结合蛋白-2 (TRX-binding protein-2，TBP-2)又称:维生素D3上调蛋白1(Vitamin D3 up-regulated protein 1，VDUP1)或称硫氧还蛋白相互作用蛋白(Thioredoxin-interacting protein，Txnip)。
    TBP-2与硫氧还蛋白(thioredoxin，TRX)的活性部位结合，抑制其活性，除了参与多种氧化应激反应，还具有多种生物学功能。
    有学者认为：TBP-2与肿瘤密切相关，有些肿瘤组织中，TBP-2表达降低或缺失。TBP-2表达增高时，细胞周期停滞，肿瘤细胞繁殖受到抑制。目前已成为肿瘤研究的重要靶点。

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