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外周苯二氮受体抗体
  • 产品货号：
    BN41873R
  • 中文名称：
    外周苯二氮受体抗体
  • 英文名称：
    Rabbit anti-TSPO/PBR Polyclonal antibody

  • 货号

    产品规格

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  • BN41873R-50ul

    50ul

    ¥1486.00

    交叉反应：Human,Mouse,Rat(predicted:Dog,Pig) 推荐应用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41873R-100ul

    100ul

    ¥2360.00

    交叉反应：Human,Mouse,Rat(predicted:Dog,Pig) 推荐应用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41873R-200ul

    200ul

    ¥3490.00

    交叉反应：Human,Mouse,Rat(predicted:Dog,Pig) 推荐应用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

英文名称TSPO/PBR
中文名称外周苯二氮受体抗体
别    名BPBS; BZRP; DBI; IBP; Isoquinoline carboxamide-binding protein; MBR; mDRC; Mitochondrial benzodiazepine receptor; PBR; PBS; Peripheral benzodiazepine receptor; Peripheral benzodiazepine receptor-related protein; Peripheral type benzodiazepine receptor; pk18; PKBS; PTBR; Ptbzr; PTBZR02; RATPTBZR02; translocator protein (18kDa); Translocator protein; TSPO; Tspo1; Benzodiazapine receptor (peripheral); Benzodiazepine peripheral binding site.  
研究领域细胞生物  免疫学  神经生物学  转录调节因子  糖尿病  线粒体  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,  (predicted: Human, Dog, Pig, )
产品应用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量18kDa
细胞定位细胞浆 线粒体
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human PBR:31-130/169 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍PBR (Peripheral type Benzodiazepine Receptor) is a ubiquitous protein (18 kDa) found in most steroidogenic tissues. It is located primarily in the outer mitochondrial membrane of steroid producing tissues and is found in association with a 34 kDa voltage dependent anion channel protein (VDAC). PBR interacts with some benzodiazepines and has different affinities than its endogenous counterpart. PBR appears to be a key factor in the transport of cholesterol from the outer to the inner mitochondrial membrane to permit the initiation of steroid hormone synthesis. It is thought to be part of the mitochondrial permeability transition pore (PT) and to be involved in apoptosis. It is speculated that patients with congenital lipoid adrenal hyperplasia, who cannot make any steroids, might have a genetic lesion in BZRP. A short form, PBRS is also expressed in the same tissues, but at a level about ten times that of PBR.

Function:
Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells.

Subcellular Location:
Mitochondrion membrane.

Tissue Specificity:
Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids.

Similarity:
Belongs to the TspO/BZRP family.

SWISS:
B1AH88

Gene ID:
706

Database links:

Entrez Gene: 706 Human

Entrez Gene: 12257 Mouse

Omim: 109610 Human

SwissProt: B1AH88 Human

SwissProt: P30536 Human

SwissProt: P50637 Mouse

Unigene: 202 Human

Unigene: 1508 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

地西泮结合抑制因子； DBI能拮抗安定物质：diazepam与脑突触膜相结合 ,故称之为安定结合抑制蛋白(DBI)，地西泮结合抑制因子(diazepam binding inhibitor,DBI)具有抑制由葡萄糖诱导的胰岛素分泌、促进胆固醇跨线粒体膜转运和调节脂肪酸合成与代谢等多种生理功能。



















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