货号
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售价
备注
BN41871R-50ul
50ul
¥1486.00
交叉反应：Human,Mouse,Rat(predicted:Dog,Pig,Horse,GuineaPig) 推荐应用：WB,ELISA
BN41871R-100ul
100ul
¥2360.00
交叉反应：Human,Mouse,Rat(predicted:Dog,Pig,Horse,GuineaPig) 推荐应用：WB,ELISA
BN41871R-200ul
200ul
¥3490.00
交叉反应：Human,Mouse,Rat(predicted:Dog,Pig,Horse,GuineaPig) 推荐应用：WB,ELISA
| 英文名称 | SUR1 |
| 中文名称 | 磺酰脲类药物受体1抗体 |
| 别 名 | ABC36; Abcc8; ATP binding cassette sub family C (CFTR/MRP) member 8; ATP binding cassette transporter sub family C member 8 (1); HHF1; HRINS; MRP8; PHHI; Sulfonylurea receptor 1; SUR. |
| 研究领域 | 免疫学 细胞膜受体 药物及化合物 糖尿病 内分泌病 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, (predicted: Human, Dog, Pig, Horse, Guinea Pig, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 175kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SUR1:301-400/1581 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | SUR1 is a member of ATP binding cassette super family. SUR receptor confers the sensitivity of Kir6.2 to ATP/ADP sensitivity and to pharmacological agents such as sulfonylurea and diazoxide that close or open the KATP channels. The persistent heyperinsulinimic hypoglycemia in infancy (PHHI) is familial disorder due to defect in negative feed back in response to low glucose levels. SUR1 was mapped on chromosome 11p14-15.1, the same location where the gene for PHHI is located. It has been shown that the expression of Kir6.2 and SUR1 are regulated by glucose levels and the actives of glucogon like peptide receptor 1. Abnormal insulin secretion in PHHI appears to be caused by mutations in the SUR gene. Subunit: Interacts with KCNJ11. Subcellular Location: Membrane; Multi-pass membrane protein. Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains. SWISS: Q09428 Gene ID: 6833 Database links: Entrez Gene: 6833 Human Entrez Gene: 20927 Mouse Omim: 600509 Human SwissProt: Q09428 Human Unigene: 54470 Human Unigene: 11187 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 胰岛β细胞膜含有磺酰脲受体及与之相偶联的ATP敏感的钾通道Ik（ATP），以及电压依赖性的钙通道。当磺酰脲类药物与其受体相结合后，可阻滞Ik（ATP）而阻钾外流，致使细胞膜去极化，增强电压依赖性钙通道开放，胞外钙内流。胞内游离钙浓度增加后，触发胞吐作用及胰岛素的释放。 |
