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CD44抗体
  • 产品货号：
    BN41831R
  • 中文名称：
    CD44抗体
  • 英文名称：
    Rabbit anti-CD44 Polyclonal antibody

  • 货号

    产品规格

    售价

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  • BN41831R-50ul

    50ul

    ¥1486.00

    交叉反应：Human,Mouse(predicted:Rat,Chicken,Pig,Cow,Rabbit) 推荐应用：Flow-Cyt,ELISA

  • BN41831R-100ul

    100ul

    ¥2360.00

    交叉反应：Human,Mouse(predicted:Rat,Chicken,Pig,Cow,Rabbit) 推荐应用：Flow-Cyt,ELISA

  • BN41831R-200ul

    200ul

    ¥3490.00

    交叉反应：Human,Mouse(predicted:Rat,Chicken,Pig,Cow,Rabbit) 推荐应用：Flow-Cyt,ELISA

英文名称CD44
中文名称CD44抗体
别    名Homing Cell Adhesion Molecule; Epican; Heparan sulfate proteoglycan; Hyaluronate receptor; Antigen gp90 homing receptor; CD44; CD44 antigen; CD44 antigen homing function and Indian blood group system; CD44 molecule; CD44 molecule Indian blood group; CD44R; CDw44; CDW44 antigen; Chondroitin sulfate proteoglycan 8; CSPG8; ECMR III; ECMRIII; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; HCELL; Hematopoietic cell E and L selectin ligand; Hermes antigen; Homing function and Indian blood group system; HUTCH I; IN ; INLU related p80 glycoprotein; LHR; MC56; MDU2; MDU3; MGC10468; MIC4; MUTCH I; MUTCHI; PGP 1; Phagocytic glycoprotein I; CD44_RAT.  





研究领域肿瘤  细胞生物  免疫学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse,  (predicted: Rat, Chicken, Pig, Cow, Rabbit, )
产品应用ELISA=1:5000-10000 Flow-Cyt=1μg/Test 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量53kDa
细胞定位细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from rat CD44v6:325-429/429 <Cytoplasmic>
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍CD44 is the receptor for hyaluronic acid (HA). It mediates cell to cell and cell matrix interactions through its affinity for HA. Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. High protein heterogeneity due to several alternative splicing and post translational modification events. CD44R represents a heterogeneous group of CD44 variant isoforms expressed constitutively in epithelial cells and monocyte lineage cells and can be upregulated in activated leukocytes. CD44R, and in particular CD44v6 containing isoforms, may be involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to sites of inflammation. CD44v6 containing isoforms may be involved in tumor metastasis.

The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq].

Function:
Main cell surface receptor for hyaluronate. Adhesion to ucosal high endothelial venule and to types I and VI collagen. robably involved in matrix adhesion, lymphocyte activation and ymph node homing.

Subunit:
Interacts with PKN2.

Subcellular Location:
Membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane protrusions at wounding edges.

Post-translational modifications:
N-glycosylated.
O-glycosylated; contains chondroitin sulfate glycans which an be more or less sulfated.
Phosphorylated; activation of PKC results in the ephosphorylation of Ser-467 (constitutive phosphorylation site), nd the phosphorylation of Ser-433.

Similarity:
Contains 1 Link domain.

SWISS:
P16070

Gene ID:
960

Database links:

Entrez Gene: 960 Human

Entrez Gene: 12505 Mouse

Entrez Gene: 25406 Rat

Omim: 107269 Human

SwissProt: P16070 Human

SwissProt: P15379 Mouse

SwissProt: P26051 Rat

Unigene: 502328 Human

Unigene: 423621 Mouse

Unigene: 1120 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD44V6参与细胞与细胞、细胞与基质问的黏附,与细胞骨架蛋白结合，并与细胞的迁移运动有关,与肿瘤细胞的浸润与转移有关。






















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