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细胞毒性受体NK-p30抗体
  • 产品货号：
    BN41818R
  • 中文名称：
    细胞毒性受体NK-p30抗体
  • 英文名称：
    Rabbit anti-NCR3 Polyclonal antibody

  • 货号

    产品规格

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  • BN41818R-50ul

    50ul

    ¥1486.00

    交叉反应：Human(predicted:Rat,Dog,Horse,Rabbit) 推荐应用：Flow-Cyt,ELISA

  • BN41818R-100ul

    100ul

    ¥2360.00

    交叉反应：Human(predicted:Rat,Dog,Horse,Rabbit) 推荐应用：Flow-Cyt,ELISA

  • BN41818R-200ul

    200ul

    ¥3490.00

    交叉反应：Human(predicted:Rat,Dog,Horse,Rabbit) 推荐应用：Flow-Cyt,ELISA

英文名称NCR3
中文名称细胞毒性受体NK-p30抗体
别    名1C7; Activating natural killer receptor p30; Activating NK A1 receptor; CD337; CD337 antigen; LY117; Lymphocyte antigen 117; MALS; Natural cytotoxicity triggering receptor 3; Natural cytotoxicity triggering receptor 3; Natural killer cell p30 related protein; Natural killer cell p30 related protein; Natural killer cell p30-related protein; Ncr3; NCTR3_HUMAN; NK-p30; NKp30.  
研究领域免疫学  干细胞  细胞表面分子  自然杀伤细胞  淋巴细胞  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,  (predicted: Rat, Dog, Horse, Rabbit, )
产品应用ELISA=1:5000-10000 Flow-Cyt=2ug/Test 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量20kDa
细胞定位细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CD337:81-180/201 <Extracellular>
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍NCR3 is a cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. It is a member of the Ig superfamily and may cooperate with NKp46 and NKp44 in the induction of cytotoxicity against a variety of target cells and is selectively expressed by all NK cells, both freshly isolated and cultured in IL2, thus representing an optimal marker for NK cell identification. Similar to NKp46 and CD16, NKp30 associated with CD3 zeta chains becomes tyrosine phosphorylated following cell treatment with pervanadate. Its extracelluar portion is characterized by a single domain of the V-type and by a region rich in hydrophobic amino acids, potentially involved in protein/protein interactions that connects the Ig V-like domain with the transmembrane portion. It is selectively expressed by all resting and activated NK cells and weakly expressed in spleen.

Function:
Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.

Subunit:
Homodimer in the unliganted form. Interacts with CD3Z. Interacts with and is activated by binding to B7H6. Interacts with and is activated by binding to BAG6.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein.

Tissue Specificity:
Selectively expressed by all resting and activated NK cells and weakly expressed in spleen.

Similarity:
Belongs to the natural cytotoxicity receptor (NCR) family.
Contains 1 Ig-like (immunoglobulin-like) domain.

SWISS:
O14931

Gene ID:
259197

Database links:

Entrez Gene: 259197 Human

Entrez Gene: 294251 Rat

Omim: 611550 Human

SwissProt: O14931 Human

SwissProt: Q8CFD9 Rat

Unigene: 509513 Human

Unigene: 203206 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

细胞毒性受体家族（NCRs）主要有：NKp46、NKp44和NKp30，其中NKp46和NKp30表达于所有静止和活化的NK细胞，而NKp44则选择性的表达于活化的NK细胞。靶细胞上的配体分子与NCRs的结合（交联）引发NK细胞的活化导致靶细胞的裂解和大量细胞因子的产生。现已确认NKp46和NKp44可以识别病毒上的配体分子红血球凝聚素，而NKp46则能识别肿瘤细胞上的乙酰硫酸多聚糖。

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