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白细胞介素1受体相关蛋白抗体
  • 产品货号：
    BN41815R
  • 中文名称：
    白细胞介素1受体相关蛋白抗体
  • 英文名称：
    Rabbit anti-ST2 Polyclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN41815R-50ul

    50ul

    ¥1486.00

    交叉反应：Rat(predicted:Mouse,Dog,Pig,Cow) 推荐应用：Flow-Cyt

  • BN41815R-100ul

    100ul

    ¥2360.00

    交叉反应：Rat(predicted:Mouse,Dog,Pig,Cow) 推荐应用：Flow-Cyt

  • BN41815R-200ul

    200ul

    ¥3490.00

    交叉反应：Rat(predicted:Mouse,Dog,Pig,Cow) 推荐应用：Flow-Cyt

英文名称ST2
中文名称白细胞介素1受体相关蛋白抗体
别    名DER-4; DER4; FIT 1; Growth stimulation expressed gene 2; homolog of mouse growth stimulation-expressed; Il1rl1; IL33R; ILRL1_HUMAN; Interleukin 1 receptor like 1; interleukin 1 receptor related protein; Interleukin-1 receptor-like 1; Ly84; Lymphocyte antigen 84; Protein ST2; ST2; ST2L; ST2V; Ste2; Suppressor of tumorigenicity 2; T1; T1 protein.


研究领域心血管  细胞生物  免疫学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Rat,  (predicted: Mouse, Dog, Pig, Cow, )
产品应用Flow-Cyt=2μg/Test 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量61kDa
细胞定位细胞膜 分泌型蛋白 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Interleukin 1 receptor like 1:11-110/556 <Extracellular>
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍ST2 is a member of a superfamily containing the Interleukin 1 (IL1) receptor and the Toll-like receptors (TLRs). The TLRs are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. ST2 was originally identified as a protein whose production was stimulated by various proliferation-inducing agents such as PDGF and FGF. More recently, it has been shown to negatively regulate IL1 receptor and Toll-like receptor 4 (TLR4) signaling and to maintain endotoxin tolerance. It has been suggested that the inhibition of TLR4 signaling occurs through the association and sequestering of TLR adaptor molecules such as MyD88 and TIRAP.

Function:
Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.

Subunit:
Interacts with MYD88, IRAK1, IRAK4, and TRAF6.

Subcellular Location:
Isoform C: Cell membrane.
Isoform B: Secreted.
Cell membrane; Single-pass type I membrane protein.

Tissue Specificity:
Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle.

Similarity:
Belongs to the interleukin-1 receptor family.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 TIR domain.

SWISS:
Q01638

Gene ID:
9173

Database links:

Entrez Gene: 9173 Human

Entrez Gene: 17082 Mouse

Omim: 601203 Human

SwissProt: Q01638 Human

SwissProt: P14719 Mouse

Unigene: 66 Human

Unigene: 289824 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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