细胞毒性受体NK-p46抗体

产品货号：

BN41809R
中文名称：

细胞毒性受体NK-p46抗体
英文名称：

Rabbit anti-NCR1 Polyclonal antibody

货号

产品规格

售价

备注
BN41809R-50ul

50ul

¥1486.00

交叉反应：Human,Mouse 推荐应用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
BN41809R-100ul

100ul

¥2360.00

交叉反应：Human,Mouse 推荐应用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
BN41809R-200ul

200ul

¥3490.00

交叉反应：Human,Mouse 推荐应用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

产品描述

英文名称	NCR1
中文名称	细胞毒性受体NK-p46抗体
别名	Natural killer cell p46-related protein; Natural cytotoxicity triggering receptor 1; NK-p46; NKp46; NK cell-activating receptor; Lymphocyte antigen 94 homolog; CD335; CD 335; LY94; NCTR1_HUMAN.
研究领域	肿瘤
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse,
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2ug/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	31kDa
细胞定位	细胞膜
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human NCR1:1-100/304 <Extracellular>
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. NCR1 is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 amino acid residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. NCR1 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. NCR1 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines. Function: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Subunit: Interacts with CD247 and FCER1G. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Selectively expressed by both resting and activated NK cells. Similarity: Belongs to the natural cytotoxicity receptor (NCR) family. Contains 2 Ig-like (immunoglobulin-like) domains. SWISS: O76036 Gene ID: 9437 Database links: Entrez Gene: 9437 Human Entrez Gene: 17086 Mouse Entrez Gene: 117547 Rat Omim: 604530 Human SwissProt: O76036 Human SwissProt: Q8C567 Mouse SwissProt: Q9Z0H5 Rat Unigene: 97084 Human Unigene: 240231 Mouse Unigene: 30049 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. NKp46是很重要的的自然细胞毒受体，在自然杀伤作用中起关键作用。细胞毒性受体家族（NCRs）主要有：NKp46、NKp44和NKp30，其中NKp46和NKp30表达于所有静止和活化的NK细胞，而NKp44则选择性的表达于活化的NK细胞。靶细胞上的配体分子与NCRs的结合（交联）引发NK细胞的活化导致靶细胞的裂解和大量细胞因子的产生。现已确认NKp46和NKp44可以识别病毒上的配体分子红血球凝聚素，而NKp46则能识别肿瘤细胞上的乙酰硫酸多聚糖。