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粘结蛋白SA2抗体
  • 产品货号：
    BN41803R
  • 中文名称：
    粘结蛋白SA2抗体
  • 英文名称：
    Rabbit anti-SA2 Polyclonal antibody

  • 货号

    产品规格

    售价

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  • BN41803R-50ul

    50ul

    ¥1486.00

    交叉反应：Human,Mouse(predicted:Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB

  • BN41803R-100ul

    100ul

    ¥2360.00

    交叉反应：Human,Mouse(predicted:Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB

  • BN41803R-200ul

    200ul

    ¥3490.00

    交叉反应：Human,Mouse(predicted:Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB

英文名称SA2
中文名称粘结蛋白SA2抗体
别    名Cohesin Subunit SA 2; Cohesin subunit SA-2; DKFZp686P168; DKFZp781H1753; SA 2; SA2; SCC3 homolog 2; STAG 2; STAG 2; stag2; STAG2_HUMAN; Stromal antigen 2; FLJ25871; bA517O1.1.  
研究领域细胞生物  细胞周期蛋白  细胞分化  表观遗传学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
产品应用WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量141kDa
细胞定位细胞核 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human SA2:1021-1120/1231 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.

Function:
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.

Subunit:
Interacts directly with RAD21 in cohesin complex. Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG2 is mutually exclusive with STAG1 and STAG3.

Subcellular Location:
Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex.

Post-translational modifications:
Phosphorylated by PLK1. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation (By similarity).

Similarity:
Belongs to the SCC3 family.
Contains 1 SCD (stromalin conservative) domain.

SWISS:
Q8N3U4

Gene ID:
10735

Database links:
UniProtKB/Swiss-Prot: Q8N3U4.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.



















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