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促甲状腺素释放激素抗体
  • 产品货号：
    BN41802R
  • 中文名称：
    促甲状腺素释放激素抗体
  • 英文名称：
    Rabbit anti-TRH/Prothyroliberin Polyclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN41802R-50ul

    50ul

    ¥1486.00

    交叉反应：Mouse,Rat(predicted:Human,Dog,Pig,Horse,Rabbit) 推荐应用：WB

  • BN41802R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse,Rat(predicted:Human,Dog,Pig,Horse,Rabbit) 推荐应用：WB

  • BN41802R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse,Rat(predicted:Human,Dog,Pig,Horse,Rabbit) 推荐应用：WB

英文名称TRH/Prothyroliberin
中文名称促甲状腺素释放激素抗体
别    名Thyrotropin releasing hormone; Protirelin; Thyroliberin [Precursor]; Thyroliberin; Thyrotropin releasing factor; TRF; TRH; TRH_HUMAN; TSH releasing factor; Prothyroliberin.  
研究领域肿瘤  神经生物学  信号转导  生长因子和激素  内分泌病  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,  (predicted: Human, Dog, Pig, Horse, Rabbit, )
产品应用WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量24kDa
细胞定位分泌型蛋白 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human TRH/Prothyroliberin:131-240/242 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013].

Function:
Thyrotropin releasing hormone (TRH) is a tripeptide hormone that stimulates the release of thyroid stimulating hormone and prolactin by the anterior pituitary. TRH is produced by the hypothalamus and travels across the median eminence to the pituitary via the hypophyseal portal system. In addition to the brain, TRH can also be detected in other areas of the body including the gastrointestinal system and pancreatic islets.

Subcellular Location:
Secreted

Tissue Specificity:
Hypothalamus. Expressed in the hair follicle epithelium (at protein level).

Similarity:
Belongs to the TRH family.

SWISS:
P20396

Gene ID:
7200

Database links:

Entrez Gene: 7200 Human

Entrez Gene: 22044 Mouse

Entrez Gene: 25569 Rat

Omim: 275120 Human

SwissProt: P20396 Human

SwissProt: Q62361 Mouse

SwissProt: P01150 Rat

Unigene: 1363 Mouse

Unigene: 22 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

促甲状腺激素释放激素(TRH)是下丘脑合成及分泌的一种下丘脑激素，它可以促进垂体促甲状腺激素的合成与分泌。促甲状腺激素释放激素的合成及分泌可以受血液中甲状腺激素的调节。血液中甲状腺激素增高(甲亢)可以抑制下丘脑促甲状腺激素释放激素(TRH)的生成，继而使垂体促甲状腺激素生成减少，甲状腺激素增高也可以直接抑制垂体促甲状腺激素的生成。血液中甲状腺激素减少(甲低)可以兴奋下丘脑促甲状腺激素释放激素(TRH)，继而引起垂体促甲状腺激素生成增加，甲状腺激素减少还可以直接兴奋垂体促甲状腺激素的生成。

















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