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配对盒基因7抗体
  • 产品货号：
    BN41799R
  • 中文名称：
    配对盒基因7抗体
  • 英文名称：
    Rabbit anti-PAX7 Polyclonal antibody

  • 货号

    产品规格

    售价

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  • BN41799R-50ul

    50ul

    ¥1486.00

    交叉反应：Mouse,Rat(predicted:Human,Chicken,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,IHC-P

  • BN41799R-100ul

    100ul

    ¥2360.00

    交叉反应：Mouse,Rat(predicted:Human,Chicken,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,IHC-P

  • BN41799R-200ul

    200ul

    ¥3490.00

    交叉反应：Mouse,Rat(predicted:Human,Chicken,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,IHC-P

英文名称PAX7
中文名称配对盒基因7抗体
别    名Paired box gene 7; FLJ37460; HUP1; OTTHUMP00000002534; Paired box 7; Paired box homeotic gene 7; Paired box protein Pax-7; Paired domain gene 7; Paired domain gene HuP1; PAX7 transcriptional factor; PAX7/FKHR fusion gene, included; PAX7B; RGD1564360; PAX7_HUMAN.  
研究领域信号转导  转录调节因子  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,  (predicted: Human, Chicken, Pig, Cow, Horse, Rabbit, Sheep, )
产品应用WB=1:500-2000 IHC-P=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量55kDa
细胞定位细胞核 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human PAX7:141-240/520 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍PAX7 is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of PAX7 is unknown but it is speculated to be involved in tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Alternative splicing in this gene has produced two known products but the biological significance of the variants is unknown.

Function:
Probable transcription factor. May have a role in myogenesis.

Subunit:
Can bind to DNA as a heterodimer with PAX3. Interacts with DAXX.

Subcellular Location:
Nucleus.

DISEASE:
Defects in PAX7 are a cause of rhabdomyosarcoma type 2 (RMS2) [MIM:268220]. It is a form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchimal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. Note=A chromosomal aberration involving PAX7 is found in rhabdomyosarcoma. Translocation t(1;13)(p36;q14) with FOXO1. The resulting protein is a transcriptional activator.

Similarity:
Belongs to the paired homeobox family.
Contains 1 homeobox DNA-binding domain.
Contains 1 paired domain.

SWISS:
P23759

Gene ID:
5081

Database links:

Entrez Gene: 5081 Human

Entrez Gene: 18509 Mouse

Entrez Gene: 500574 Rat

Omim: 167410 Human

SwissProt: P23759 Human

SwissProt: P47239 Mouse

Unigene: 113253 Human

Unigene: 218760 Mouse

Unigene: 226327 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

同源结构域蛋白（Homeodomain Proteins）
PAX-7属于转录抑制因子。在胚胎发育和肿瘤生长中起关键作用。其突变和某些肿瘤的发病有关。

















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