整合素相关蛋白CD47

产品货号：

BN41787R
中文名称：

整合素相关蛋白CD47
英文名称：

Rabbit anti-CD47 Polyclonal antibody

货号

产品规格

售价

备注
BN41787R-50ul

50ul

¥1486.00

交叉反应：Human 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA
BN41787R-100ul

100ul

¥2360.00

交叉反应：Human 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA
BN41787R-200ul

200ul

¥3490.00

交叉反应：Human 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

产品描述

英文名称	CD47
中文名称	整合素相关蛋白CD47
别名	Antigenic surface determinant protein OA3; CD 47; CD47; CD47 antigen; CD47 glycoprotein; CD47 molecule; CD47_HUMAN; IAP; Integrin Associated Protein; Integrin associated signal transducer; Integrin-associated protein; Leukocyte surface antigen CD47; MER 6; MER6; OA 3; OA3; Protein MER6; Rh related antigen.
研究领域	肿瘤神经生物学细胞粘附分子
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human,
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	33kDa
细胞定位	细胞膜
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human CD47:19-119/323 <Extracellular>
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]. Function: Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection. Subunit: Interacts with THBS1 and fibrinogen (By similarity). Monomer. Interacts with SIRPA, SIRPG, UBQLN1 and UBQLN2. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain. SWISS: Q08722 Gene ID: 961 Database links: Entrez Gene: 961 Human Entrez Gene: 16423 Mouse Entrez Gene: 29364 Rat Omim: 601028 Human SwissProt: Q08722 Human SwissProt: Q61735 Mouse SwissProt: P97829 Rat Unigene: 446414 Human Unigene: 31752 Mouse Unigene: 390865 Mouse Unigene: 7409 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.