信号转导和转录激活因子5抗体

产品货号：

BN41786R
中文名称：

信号转导和转录激活因子5抗体
英文名称：

Rabbit anti-STAT5 Polyclonal antibody

货号

产品规格

售价

备注
BN41786R-50ul

50ul

¥1486.00

交叉反应：Human,Mouse(predicted:Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,IHC-P,ELISA
BN41786R-100ul

100ul

¥2360.00

交叉反应：Human,Mouse(predicted:Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,IHC-P,ELISA
BN41786R-200ul

200ul

¥3490.00

交叉反应：Human,Mouse(predicted:Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,IHC-P,ELISA

产品描述

英文名称	STAT5
中文名称	信号转导和转录激活因子5抗体
别名	signal transducers and activators of transduction 5; MGF; Signal Transducer and Activator of Transcription 5A; STAT 5; STAT 5A; STAT 5B; STAT5A; STAT5B; Transcription factor STAT5A; STA5B_HUMAN; STA5A_HUMAN.
研究领域	免疫学信号转导转录调节因子
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	90kDa
细胞定位	细胞核细胞浆
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human STAT5:1-100/794
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. [provided by RefSeq, Jul 2008] Function: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation. Subunit: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1. Interacts with NCOA1 and SOCS7. Interacts with ERBB4. Subcellular Location: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation. Post-translational modifications: Tyrosine phosphorylated in response to KITLG/SCF, IL2, IL3, IL7, IL15, CSF2/GMCSF, GH1, PRL, EPO and THPO. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity). Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2 at Tyr-694. Similarity: Belongs to the transcription factor STAT family. Contains 1 SH2 domain. SWISS: P42229 Gene ID: 6776 Database links: Entrez Gene: 6776 Human Entrez Gene: 6777 Human Entrez Gene: 20850 Mouse Entrez Gene: 20851 Mouse Entrez Gene: 24918 Rat Entrez Gene: 25126 Rat Entrez Gene: 443419 Sheep Omim: 601511 Human Omim: 604260 Human SwissProt: Q95115 Cow SwissProt: Q9TUM3 Cow SwissProt: P42229 Human SwissProt: P51692 Human SwissProt: P42230 Mouse SwissProt: P42232 Mouse SwissProt: P52632 Rat SwissProt: Q62771 Rat SwissProt: P42231 Sheep Unigene: 437058 Human Unigene: 277403 Mouse Unigene: 154399 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 转录调节因子（Transcriptin Regulators） STAT-信号转导和转录激活因子蛋白家族是近年来发现的一类转录因子.通过JAK-STAT途径介导许多由细胞因子诱导的反应,参与细胞的信号转导和转录。