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VP16 tag抗体
  • 产品货号：
    BN41780R
  • 中文名称：
    VP16 tag抗体
  • 英文名称：
    Rabbit anti-VP16 tag Polyclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN41780R-50ul

    50ul

    ¥1486.00

    交叉反应：Species independent 推荐应用：WB,ELISA

  • BN41780R-100ul

    100ul

    ¥2360.00

    交叉反应：Species independent 推荐应用：WB,ELISA

英文名称VP16 tag
中文名称VP16 tag抗体
别    名VP16_HHV1F;UL48; Tegument protein VP16; Alpha trans-inducing protein; Alpha-TIF; ICP25; Vmw65  
研究领域免疫学  细菌及病毒  
抗体来源Rabbit
克隆类型Polyclonal
产品应用WB=1:1000-5000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量54kDa
细胞定位细胞核 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from HSV-1 VP16:391-490/490aa 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍HSV evades the immune system through interference with MHC class I antigen presentation on the cell surface, by blocking TAP or the transporter associated with antigen processing induced by the secretion of ICP-47 by HSV. In the host cell, TAP transports digested viral antigen epitope peptides from the cytosol to the endoplasmic reticulum, allowing these epitopes to be combined with MHC class I molecules and presented on the surface of the cell. Viral epitope presentation with MHC class I is a requirement for activation of cytotoxic T-lymphocytes (CTLs), the major effectors of the cell-mediated immune response against virally-infected cells. ICP-47 prevents initiation of a CTL-response against HSV, allowing the virus to survive for a protracted period in the host.

Function:
Transcriptional activator of immediate-early (IE) gene products (alpha genes). Acts as a key activator of lytic infection by initiating the lytic program through the assembly of the transcriptional regulatory VP16-induced complex composed of VP16 and two cellular factors, HCFC1 and POU2F 1. VP16-induced complex represents a regulatory switch: when it is on, it promotes IE-gene expression and thus lytic infection, and when it is off, it limits IE-gene transcription favoring latent infection (By similarity).
May play a role in the aggregation of tegument proteins around nucleocapsids during virus morphogenesis.

Subunit:
Interacts with VP22. Interacts with gH (via C-terminus). Interacts with the virion host shutoff protein (vhs). Interacts with VP11/12. Associates with the VP16-induced complex; binding to host HCFC1 activates VP16 for association with the octamer motif-binding host protein POU2F1, to form a multiprotein-DNA complex responsible for activating transcription of the viral immediate early genes (By similarity).

Similarity:
Belongs to the herpesviridae tegument protein VP16 protein family.

SWISS:
P04486

Gene ID:
VP16 tag

Database links:

SwissProt: P04486 Human herpesvirus 1



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

















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