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溶酶体相关膜蛋白1抗体
  • 产品货号：
    BN41765R
  • 中文名称：
    溶酶体相关膜蛋白1抗体
  • 英文名称：
    Rabbit anti-LAMP1 Polyclonal antibody

  • 货号

    产品规格

    售价

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  • BN41765R-50ul

    50ul

    ¥1486.00

    交叉反应：Rat,Human(predicted:Pig,Mouse) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN41765R-100ul

    100ul

    ¥2360.00

    交叉反应：Rat,Human(predicted:Pig,Mouse) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN41765R-200ul

    200ul

    ¥3490.00

    交叉反应：Rat,Human(predicted:Pig,Mouse) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

英文名称LAMP1
中文名称溶酶体相关膜蛋白1抗体
别    名CD107 antigen like family member A; CD107 antigen-like family member A; CD107a; CD107a antigen; LAMP 1; LAMP-1; LAMP1_HUMAN; LAMPA; LGP120; lgpA; Lysosomal membrane glycoprotein 120KD; Lysosomal Associated Membrane Protein 1; Lysosome associated membrane glycoprotein 1; Lysosome-associated membrane glycoprotein 1; Lysosome-associated membrane glycoprotein 1; Lysosome-associated membrane protein 1; OTTHUMP00000040663.  




研究领域肿瘤  免疫学  神经生物学  信号转导  干细胞  新陈代谢  细胞膜蛋白  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, 
产品应用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg /test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量42kDa
细胞定位细胞浆 细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human LAMP-1:301-417/417 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.

Function:
Presents carbohydrate ligands to selectins. Also mplicated in tumor cell metastasis.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane.

Post-translational modifications:
O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans.

Similarity:
Belongs to the LAMP family.

SWISS:
P11279

Gene ID:
3916

Database links:

Entrez Gene: 3916 Human

Entrez Gene: 16783 Mouse

Entrez Gene: 25328 Rat

Omim: 153330 Human

SwissProt: P11279 Human

SwissProt: P11438 Mouse

SwissProt: P14562 Rat

Unigene: 494419 Human

Unigene: 16716 Mouse

Unigene: 475822 Mouse

Unigene: 40177 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD107a可很好的反映NK细胞活性，其表达水平的上调与NK分泌细胞因子的增多及NK对靶细胞的杀伤作用的增强高度相关，采用流式检测，CD107a还可鉴定出一群无细胞因子分泌的活性NK细胞。

















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