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BN41743R-50ul
50ul
¥1486.00
交叉反应：Human,Mouse,Rat,Cow(predicted:Chicken,Dog,Pig,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
BN41743R-100ul
100ul
¥2360.00
交叉反应：Human,Mouse,Rat,Cow(predicted:Chicken,Dog,Pig,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
BN41743R-200ul
200ul
¥3490.00
交叉反应：Human,Mouse,Rat,Cow(predicted:Chicken,Dog,Pig,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
| 英文名称 | Pan Cytokeratin |
| 中文名称 | 广谱细胞角蛋白PCK抗体 |
| 别 名 | pan-cytokeratin; pan-CK; pan CK; P-CK; wide spectrum Cytokeratin; Cytokeratins; [cytokeratins 1,2,4,5,6,7,8,71,72,75,78]. |
| 研究领域 | 肿瘤 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, (predicted: Chicken, Dog, Pig, Horse, Rabbit, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg /test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 42-64kDa |
| 细胞定位 | 细胞浆 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human cytokeratins 1,2,4,5,6,7,8,71,72,75,78: |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | Cytokeratins are proteins of keratin-containing intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. The cytokeratins are encoded by a family encompassing 30 genes. Among them, 20 are epithelial genes and the remaining 10 are specific for trichocytes. In the cytoplasm, the keratin filaments conform a complex network which extends from the surface of the nucleus to the cell membrane. Numerous accessory proteins are involved in the genesis and maintenance of such structure. This association between the plasma membrane and the nuclear surface provides important implications for the organization of the cytoplasm and cellular communication mechanisms. Apart from the relatively static functions provided in terms of supporting the nucleus and providing tensile strength to the cell, the cytokeratin networks undergo rapid phosphate exchanges mediated depolymerization, with important implications in the more dynamic cellular processes such as mitosis and post-mitotic period, cell movement and differentiation. Cytokeratins interact with desmosomes and hemidesmosomes, thus collaborating to cell-cell adhesion and basal cell-underlying connective tissue connection. Subcellular Location: Cytoplasmic. Tissue Specificity: epithelial cells SWISS: N/A Gene ID: Pan Cytokeratin Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. P-CK广谱细胞角蛋白（AE1/AE3）主要标记角化上皮、复层鳞状上皮、复层上皮、增生的角化上皮和单层上皮，用于鳞癌，各种腺癌 、移行上皮癌，小细胞癌，恶性间皮瘤、生殖细胞肿瘤，部分滑膜肉瘤、平滑肌肉瘤等表达。 |
