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组蛋白去乙酰化酶1（核内参）抗体
  • 产品货号：
    BN41710R
  • 中文名称：
    组蛋白去乙酰化酶1（核内参）抗体
  • 英文名称：
    Rabbit anti-HDAC1 (Nuclear Loading Control) Polyclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN41710R-50ul

    50ul

    ¥1486.00

    交叉反应：Human,Mouse,GuineaPig(predicted:Rat,Dog,Pig,Cow,Sheep) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41710R-100ul

    100ul

    ¥2360.00

    交叉反应：Human,Mouse,GuineaPig(predicted:Rat,Dog,Pig,Cow,Sheep) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41710R-200ul

    200ul

    ¥3490.00

    交叉反应：Human,Mouse,GuineaPig(predicted:Rat,Dog,Pig,Cow,Sheep) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

英文名称HDAC1 (Nuclear Loading Control)
中文名称组蛋白去乙酰化酶1（核内参）抗体
别    名DKFZp686H12203; GON 10; HD 1; HD1; HDAC 1; hdac1: histone deacetylase 1; Histone deacetylase 1 (HD1); Histone deacetylase 1; RPD3 (reduced potassium dependency yeast homolog) like 1; RPD3 (reduced potassium dependency); RPD3; RPD3L1; HDAC1_HUMAN.   


产品类型内参抗体 
研究领域肿瘤  心血管  发育生物学  干细胞  转录调节因子  表观遗传学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Sheep, Guinea Pig, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-300 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量53kDa
细胞定位细胞核 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human HDAC1:381-482/482 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]

Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Component a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.

Subcellular Location:
Nucleus.

Tissue Specificity:
Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.

Post-translational modifications:
Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.
Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes. Phosphorylated by CDK5.
Ubiquitinated by CHFR, leading to its degradation by the proteasome. Ubiquitinated by KCTD11, leading to proteasomal degradation.

Similarity:
Belongs to the histone deacetylase family. HD type 1 subfamily.

SWISS:
Q13547

Gene ID:
3065

Database links:

Entrez Gene: 3065 Human

Entrez Gene: 433759 Mouse

Entrez Gene: 297893 Rat

Entrez Gene: 404126 Cow

Omim: 601241 Human

SwissProt: Q32PJ8 Cow

SwissProt: Q13547 Human

SwissProt: O09106 Mouse

SwissProt: Q4QQW4 Rat

Unigene: 88556 Human

Unigene: 202504 Mouse

Unigene: 391033 Mouse

Unigene: 1863 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

组蛋白去乙酰化酶(HDACs)是一组在细胞染色质水平、通过诱导组蛋白去乙酰化来调控包括染色质重组、转录活化或抑制、细胞周期、细胞分化及细胞凋亡等一系列生物学效应的酶，特别是与细胞活化后的基因转录表达调控有关。

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