货号
产品规格
售价
备注
BN41660R-50ul
50ul
¥1486.00
交叉反应：Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41660R-100ul
100ul
¥2360.00
交叉反应：Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41660R-200ul
200ul
¥3490.00
交叉反应：Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
| 英文名称 | SPARC |
| 中文名称 | 富含半胱氨酸的酸性分泌蛋白抗体 |
| 别 名 | AA517111; Basement membrane protein 40; BM 40; BM40; Cysteine rich protein; hm:zeh0062; MGC128090; ON; Osteonectin; Secreted acidic cystein rich glycoprotein; Secreted protein acidic and rich in cysteine; Secreted protein acidic cysteine rich (osteonectin); Secreted protein acidic cysteine rich; SPRC; SPRC_HUMAN. |
| 研究领域 | 肿瘤 细胞生物 信号转导 干细胞 细胞周期蛋白 细胞骨架 细胞外基质 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, (predicted: Dog, Pig, Cow, Horse, Rabbit, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 33kDa |
| 细胞定位 | 细胞膜 细胞外基质 分泌型蛋白 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SPARC:101-200/303 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. [provided by RefSeq, Dec 2011]. Function: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. Subcellular Location: Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around the basement membrane. Similarity: Belongs to the SPARC family. Contains 1 EF-hand domain. Contains 1 follistatin-like domain. Contains 1 Kazal-like domain. SWISS: P09486 Gene ID: 6678 Database links: Entrez Gene: 6678 Human Omim: 182120 Human SwissProt: P09486 Human Unigene: 111779 Human Unigene: 708558 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. SPARC是从多方面调节细胞功能的细胞外基质蛋白，SPARC蛋白在人组织中广泛分布与组织重建和肿瘤有关。SPARC在多种肿瘤中呈高表达. |
