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轴突相关CNTP2蛋白抗体（少突胶质细胞）
  • 产品货号：
    BN41656R
  • 中文名称：
    轴突相关CNTP2蛋白抗体（少突胶质细胞）
  • 英文名称：
    Rabbit anti-Caspr2 Polyclonal antibody

  • 货号

    产品规格

    售价

    备注

  • BN41656R-50ul

    50ul

    ¥1486.00

    交叉反应：Human,Rat 推荐应用：WB,ELISA

  • BN41656R-100ul

    100ul

    ¥2360.00

    交叉反应：Human,Rat 推荐应用：WB,ELISA

  • BN41656R-200ul

    200ul

    ¥3490.00

    交叉反应：Human,Rat 推荐应用：WB,ELISA

英文名称Caspr2
中文名称轴突相关CNTP2蛋白抗体（少突胶质细胞）
别    名Cell recognition molecule Caspr2; Cntnap2; CNTP2; CNTP2_HUMAN; Contactin-associated protein-like 2.  
研究领域神经生物学  细胞粘附分子  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Rat, 
产品应用WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=3ug/Test 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量145kDa
细胞定位细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Caspr2:801-900/1331 <Extracellular>
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍CASPR is a transmembrane glycoprotein of the neurexin superfamily that is highly enriched in regions of myelinated axons. The axons of myelinated nerves in the adult nervous system possess specialized subcellular structures essential for efficient and rapid action potential propagation. CASPR and the closely related molecule CASPR2, a mammalian homolog of Drosophila Neurexin IV (Nrx-IV), demarcate distinct subdomains in myelinated axons. While CASPR is present at the paranodal junctions, CASPR2 is precisely colocalized with Shaker-like K+ channels in the juxtaparanodal region. CASPR2 specifically associates with Kv1.1, Kv1.2, and their Kvbeta2 subunit. CASPR family members may play a role in the local differentiation of the axon into distinct functional subdomains.

Function:
May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction.

Subunit:
Associates with KCNA2.

Subcellular Location:
Membrane.

Tissue Specificity:
Predominantly expressed in nervous system.

DISEASE:
Defects in CNTNAP2 are the cause of cortical dysplasia-focal epilepsy syndrome (CDFES) [MIM:610042]. Affected individuals manifest cortical dysplasia, focal epilepsy, relative macrocephaly, and diminished deep-tendon reflexes. Intractable focal seizures begin in early childhood, after which language regression, hyperactivity, impulsive and aggressive behavior, and mental retardation develop.
Genetic variations in CNTNAP2 influences susceptibility to autism type 15 (AUTS15) [MIM:612100]. Autism is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior. Note=A chromosomal aberration involving CNTNAP2 is found in a patient with autism spectrum disorder. Paracentric inversion 46,XY,inv(7)(q11.22;q35). The inversion breakpoints disrupt the genes AUTS2 and CNTNAP2.

Similarity:
Belongs to the neurexin family.
Contains 2 EGF-like domains.
Contains 1 F5/8 type C domain.
Contains 1 fibrinogen C-terminal domain.
Contains 4 laminin G-like domains.

SWISS:
Q9UHC6

Gene ID:
26047

Database links:

Entrez Gene: 26047 Human

Entrez Gene: 66797 Mouse

Omim: 604569 Human

SwissProt: Q9UHC6 Human

SwissProt: Q9CPW0 Mouse

Unigene: 655684 Human

Unigene: 440084 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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