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白介素12抗体
  • 产品货号:
    BN41588R
  • 中文名称:
    白介素12抗体
  • 英文名称:
    Rabbit anti-IL12 Polyclonal antibody
  • 货号

    产品规格

    售价

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  • BN41588R-50ul

    50ul

    ¥1486.00

    交叉反应:Mouse,Rat 推荐应用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41588R-100ul

    100ul

    ¥2360.00

    交叉反应:Mouse,Rat 推荐应用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41588R-200ul

    200ul

    ¥3490.00

    交叉反应:Mouse,Rat 推荐应用:WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

英文名称IL12
中文名称白介素12抗体
别    名IL12; IL-12; CLMF p35; CLMF1; CTL maturation factor (TcMF); Cytotoxic lymphocyte maturation factor 1; Cytotoxic lymphocyte maturation factor 35 kDa subunit; IL 12 subunit p35; IL12A; Interleukin 12 alpha chain; Interleukin 12 p35; Interleukin 12A; Natural killer cell stimulatory factor 1; CLMF; CLMF p35; Cytotoxic lymphocyte maturation factor 35 kDa subunit; IL-12 subunit p35; IL-12A; IL12 subunit p35; IL12A; IL12A_HUMAN; Interleukin 12 p35; Interleukin 12A; Interleukin-12 subunit alpha; NFSK; NK cell stimulatory factor chain 1; NKSF1. NK cell stimulatory factor chain 1; NKSF1; p35; IL12A_MOUSE.  


研究领域肿瘤  细胞生物  免疫学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat, 
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量22kDa
细胞定位细胞膜 分泌型蛋白 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from mouse IL-12:51-150/215 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍IL-12 protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.

Function:
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.

Subunit:
Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.

Subcellular Location:
Secreted.

Similarity:
Belongs to the IL-6 superfamily.

SWISS:
P43431

Gene ID:
16159

Database links:

Entrez Gene: 3592 Human

Entrez Gene: 16159 Mouse

Entrez Gene: 84405 Rat

Omim: 161560 Human

SwissProt: P29459 Human

SwissProt: P43431 Mouse

SwissProt: Q9R103 Rat

Unigene: 673 Human

Unigene: 103783 Mouse

Unigene: 207199 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

IL-12是新近发现的细胞因子,具有多种生物学活性,尤其是在抗肿瘤免疫和抗病毒免疫中有重要的作用。

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