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成纤维细胞生长因子8抗体
  • 产品货号：
    BN41581R
  • 中文名称：
    成纤维细胞生长因子8抗体
  • 英文名称：
    Rabbit anti-FGF8 Polyclonal antibody

  • 货号

    产品规格

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  • BN41581R-50ul

    50ul

    ¥1486.00

    交叉反应：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Sheep) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41581R-100ul

    100ul

    ¥2360.00

    交叉反应：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Sheep) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41581R-200ul

    200ul

    ¥3490.00

    交叉反应：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Sheep) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

英文名称FGF8
中文名称成纤维细胞生长因子8抗体
别    名AIGF; Androgen induced growth factor; Androgen-induced growth factor; FGF 8; FGF-8; FGF8; Fibroblast growth factor 8 (androgen induced); Fibroblast growth factor 8 precursor; HBGF 8; HBGF-8; HBGF8; FGF8_HUMAN. 



研究领域肿瘤  细胞生物  免疫学  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Rat,  (predicted: Human, Mouse, Chicken, Dog, Pig, Cow, Sheep, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量27kDa
细胞定位分泌型蛋白 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human FGF8:131-233/233 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Keratinocyte growth factor precursor (KGF) (Fibroblast growth factor 8; FGF-8; HBGF-8). Stimulates growth of the cells in an autocrine manner. Mediates hormonal action on the growth of cancer cells. Cooperates with Wnt-1 in mouse mammary tumor virus-induced murine mammary tumorigenesis. [Subcellular location] Secreted. [Tissue specificity] Absent in normal mammary glands and detected only in adult testis and ovary and in midgestational embryos. [Induction] By androgens. Belongs to the heparin-binding growth factors family.

Function:
Stimulates growth of the cells in an autocrine manner. Mediates hormonal action on the growth of cancer cells.

Subunit:
Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.

Subcellular Location:
Secreted.

DISEASE:
Defects in FGF8 are the cause of Kallmann syndrome type 6 (KAL6) [MIM:612702]. Kallmann syndrome is a disorder that associates hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous.

Similarity:
Belongs to the heparin-binding growth factors family.

SWISS:
P37237

Gene ID:
2253

Database links:

Entrez Gene: 2253 Human

Entrez Gene: 14179 Mouse

Entrez Gene: 29349 Rat

Omim: 600483 Human

SwissProt: P55075 Human

SwissProt: P37237 Mouse

Unigene: 57710 Human

Unigene: 4012 Mouse

Unigene: 73565 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

有研究者认为：纤维母细胞生长因子8 FGF8 对癌症具有一定的抑制作用。
早期研究FGF8，认为是自分泌生长因子，它在前列腺癌、乳癌和卵巢癌中常常表现过量表达 (over-expressed)，并与前列腺癌的格里森分数 (Gleason score) 相关联。经过各种细胞和动物模型的实验均支持FGF8在抑制肿瘤形成和肿瘤细胞成活方面的作用。
此外，还有学者认为：FGF8 还在实验中显示出，他有改善因胶原蛋白引发的关节炎性的改变，如：风湿性关节炎和类风湿性关节炎及退行性骨性关节病。




















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