环氧合酶2/前列腺素内过氧化物合成酶2抗体

产品货号：

BN41580R
中文名称：

环氧合酶2/前列腺素内过氧化物合成酶2抗体
英文名称：

Rabbit anti-Cyclooxygenase 2 Polyclonal antibody

货号

产品规格

售价

备注
BN41580R-50ul

50ul

¥1486.00

交叉反应：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Rabbit,Sheep,Recombinant fragment,) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41580R-100ul

100ul

¥2360.00

交叉反应：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Rabbit,Sheep,Recombinant fragment,) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41580R-200ul

200ul

¥3490.00

交叉反应：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Rabbit,Sheep,Recombinant fragment,) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

产品描述

英文名称	Cyclooxygenase 2
中文名称	环氧合酶2/前列腺素内过氧化物合成酶2抗体
别名	COX 2; COX2; COX-2; Cyclooxygenase; Cyclooxygenase2; hCox 2; PGG/HS; PGH synthase 2; PGHS 2; PGHS2; PHS 2; PHS II; PHS2 ; Prostaglandin endoperoxide synthase 2; Prostaglandin G/H synthase 2 precursor; Prostaglandin G/H synthase and cyclooxygenase; Prostaglandin G/H synthase; Prostaglandin H2 synthase 2; PTGS2; TIS10II; PGH2_HUMAN.

研究领域	肿瘤免疫学生长因子和激素合成与降解
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, (predicted: Dog, Pig, Cow, Rabbit, Sheep, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	65kDa
细胞定位	细胞浆
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Cyclooxygenase 2:501-604/604
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009] Function: Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. Subunit: Homodimer. Subcellular Location: Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Post-translational modifications: S-nitrosylation by NOS2 (iNOS) activates enzme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-561. Similarity: Belongs to the prostaglandin G/H synthase family. Contains 1 EGF-like domain. SWISS: Q05769 Gene ID: 5743 Database links: Entrez Gene: 5743 Human Entrez Gene: 19225 Mouse Entrez Gene: 29527 Rat Omim: 600262 Human SwissProt: P35354 Human SwissProt: Q05769 Mouse SwissProt: P35355 Rat Unigene: 196384 Human Unigene: 292547 Mouse Unigene: 44369 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 合成与降解（Synthesis and Degradation） COX-2 前列腺素氧化环化酶-2是前列腺素合成的关键酶之一，为诱导性酶，他参与细胞对生长因子、肿瘤促进因子和细胞因子的反应，这些因子均能诱导COX2表达，它也参与前列腺素的合成。 COX2在80-90％的人结肠腺癌中表达显著增高，而COX1表达却不变。