钙/钙调素依赖蛋白激酶2α抗体

产品货号：

BN41553R
中文名称：

钙/钙调素依赖蛋白激酶2α抗体
英文名称：

Rabbit anti-CaMK2 alpha Polyclonal antibody

货号

产品规格

售价

备注
BN41553R-50ul

50ul

¥1486.00

交叉反应：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,GuineaPig) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41553R-100ul

100ul

¥2360.00

交叉反应：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,GuineaPig) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41553R-200ul

200ul

¥3490.00

交叉反应：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,GuineaPig) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

产品描述

英文名称	CaMK2 alpha
中文名称	钙/钙调素依赖蛋白激酶2α抗体
别名	alpha CaMKII; CaMKII alpha; Calcium / Calmodulin Dependent Protein Kinase II G; Calcium calmodulin dependent protein kinase CaM kinase II alpha; Calcium calmodulin dependent protein kinase II alpha-B subunit; Calcium calmodulin dependent protein kinase II; Calcium/calmodulin dependent protein kinase II alpha; Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; Calcium/calmodulin-dependent protein kinase II alpha; Calcium/calmodulin-dependent protein kinase II-alpha; Calcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase type IIA; CaM kinase II alpha chain; CaM kinase II alpha subunit; CaM kinase II subunit alpha; CAM2; CaMK II alpha subunit; CaMK-II subunit alpha; CAMK2A; CAMKA; CAMKB; CaMKII; CaMK 2a; CaMK2a; KCC2A_HUMAN.
研究领域	激酶和磷酸酶
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, (predicted: Chicken, Dog, Pig, Cow, Guinea Pig, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=0.2ug/test IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	54kDa
细胞定位	细胞膜
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human CaMK2a:401-478/478
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]. Function: CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. Subunit: CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with BAALC, MPDZ, SYN1, CAMK2N2 and SYNGAP1. Subcellular Location: Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse. Note=Postsynaptic lipid rafts. Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Contains 1 protein kinase domain. SWISS: Q9UQM7 Gene ID: 815 Database links: Entrez Gene: 815 Human Entrez Gene: 12322 Mouse Entrez Gene: 25400 Rat Omim: 114078 Human SwissProt: Q9UQM7 Human SwissProt: P11798 Mouse SwissProt: P11275 Rat Unigene: 725992 Human Unigene: 131530 Mouse Unigene: 107499 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CaMK2a也是丝/苏氨基酸激酶的一种，同属于Ca++/钙调素依赖性蛋白质激酶家族成员。