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脂肪细胞增强结合蛋白1
  • 产品货号：
    BN41527R
  • 中文名称：
    脂肪细胞增强结合蛋白1
  • 英文名称：
    Rabbit anti-AEBP1 Polyclonal antibody

  • 货号

    产品规格

    售价

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  • BN41527R-50ul

    50ul

    ¥1486.00

    交叉反应：Rat,Mouse,Human 推荐应用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41527R-100ul

    100ul

    ¥2360.00

    交叉反应：Rat,Mouse,Human 推荐应用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41527R-200ul

    200ul

    ¥3490.00

    交叉反应：Rat,Mouse,Human 推荐应用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

英文名称AEBP1
中文名称脂肪细胞增强结合蛋白1
别    名AE binding protein 1; ACLP; Adipocyte enhancer binding protein 1; AEBP 1; AEBP1; Aortic carboxypeptidase like protein ACLP;Aortic carboxypeptidase like protein; FLJ33612; AEBP1_HUMAN; Adipocyte enhancer-binding protein 1; AE-binding protein 1; Aortic carboxypeptidase-like protein.  
研究领域免疫学  染色质和核信号  转录调节因子  结合蛋白  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,  (predicted: Mouse, Rat, )
产品应用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/test IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量128/80kDa
细胞定位细胞核 细胞浆 分泌型蛋白 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human AEBP1:101-200/728 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma. [provided by RefSeq, May 2013].

Function:
May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.

Subunit:
Interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN. May interact with calmodulin. Binds to DNA in vitro.

Subcellular Location:
Isoform 1: Secreted.
Isoform 2: Cytoplasm (Probable). Nucleus (Probable).

Tissue Specificity:
Expressed in osteoblast and visceral fat.

Post-translational modifications:
Phosphorylated by MAPK1 in vitro.

Similarity:
Belongs to the peptidase M14 family.
Contains 1 F5/8 type C domain.

SWISS:
Q14113

Gene ID:
165

Database links:

Entrez Gene: 165 Human

Omim: 602981 Human

SwissProt: Q14113 Human

Unigene: 439463 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
















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