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D型-过氧化酶活化增生受体抗体
  • 产品货号：
    BN41520R
  • 中文名称：
    D型-过氧化酶活化增生受体抗体
  • 英文名称：
    Rabbit anti-PPAR delta + beta Polyclonal antibody

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  • BN41520R-50ul

    50ul

    ¥1486.00

    交叉反应：Human,Mouse(predicted:Rat) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41520R-100ul

    100ul

    ¥2360.00

    交叉反应：Human,Mouse(predicted:Rat) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41520R-200ul

    200ul

    ¥3490.00

    交叉反应：Human,Mouse(predicted:Rat) 推荐应用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

英文名称PPAR delta + beta
中文名称D型-过氧化酶活化增生受体抗体
别    名PPAR delta+beta; FAAR; MGC3931; NR1C2; NUC1; NUCI; NUCII; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferative activated receptor delta; Peroxisome proliferator-activated receptor beta (PPAR-beta); Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR beta; PPAR-beta; PPAR-delta; PPAR-? PPARB; PPARD; PPARD_HUMAN.  
研究领域心血管  免疫学  细胞膜受体  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,  (predicted: Mouse, Rat, )
产品应用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量48kDa
细胞定位细胞核 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from mouse PPAR-delta:2-100/440 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Heterodimer with the retinoid X receptor. Subcellular located at nuclear Tissue specificity: Heart, adrenal and intestine. Belongs to the nuclear hormone receptor family. NR1 subfamily. It Contains 1 nuclear receptor DNA-binding domain.

Function:
Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.

Subcellular Location:
Nucleus.

Tissue Specificity:
Ubiquitous with maximal levels in placenta and skeletal muscle.

Similarity:
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.

SWISS:
P35396

Gene ID:
5467

Database links:

Entrez Gene: 5467 Human

Entrez Gene: 19015 Mouse

Entrez Gene: 25682 Rat

Omim: 600409 Human

SwissProt: Q03181 Human

SwissProt: P35396 Mouse

Unigene: 696032 Human

Unigene: 328914 Mouse

Unigene: 96181 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

类固醇受体（Steroid Receptors）
研究人员指出该分子的功能，极可能就是阻断心血管免疫发炎反应的讯号传递过程。PPAR－delta基因是控制肌肉发展的重要基因，在增加老鼠耐力的同时还能帮助它燃烧掉脂肪，研究人员发现，对于与新陈代谢有关的各项疾病，从心脏病到肥胖症都有启发性的意义，他可以阻止脂肪沉淀在动脉壁上，进而防止动脉硬化症的发生,该蛋白参与脂肪代谢、肥胖、糖尿病、动脉硬化和癌症的发病。
在动脉硬化现象发生的早期，免疫细胞会促使血管慢性的发炎，因而造成血管不断地吸收和输送脂肪，进而导致脂肪的堆积与血管硬化，而PPAR-delta就像警卫分子一样，时时降低发炎反应和抑制动脉硬化斑的形成，因此该分子应该是相关药物研发，相当值得切入的目标。
研究人员认为，这个发现将给药厂研发治疗心血管疾病的新药提供新的线索。



















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